Human Anti-Human NTRK1 Recombinant Antibody scFv Fragment (CRB0089) (CAT#: TAB-170CQ-S(P))
This antibody recognises and binds to an epitope comprised in the TrkA amino acid sequence and inhibits NGF-mediated proliferative response in a dose dependent manner with an IC50 of approximately 43 nM. It is potentially useful in the treatment of diseases, including osteoarthritis pain and chronic pain.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76570/1680_E8_5_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76570/1680_E8_5_selected.jpg
Figure 2 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/ihc_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/ihc_selected.jpg
Figure 3 IHC staining of human cerebellum
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4606/ihc_selected.jpg
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4606/ihc_selected.jpg
Figure 4 Cerebral cortex
(Glial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_B_9_5.jpg
(Glial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_B_9_5.jpg
Figure 5 Colon
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_9_3.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_9_3.jpg
Figure 6 Testis
(Elongated or late spermatids
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_6_6.jpg
(Elongated or late spermatids
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:
Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/35799/129189_A_6_6.jpg
Figure 7 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198400-NTRK1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198400-NTRK1
Figure 7 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198400-NTRK1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198400-NTRK1
Specifications
- Host Species
- Human
- Derivation
- Human SPLINT libraries
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Human, Mouse
- Clone
- CRB0089
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Flow Cytometry; Western Blot
- Related Disease
- Osteoarthritis pain, chronic pain
Target
- Alternative Names
- NTRK1; Neurotrophic receptor tyrosine kinase 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein
- Gene ID
- 4914
- UniProt ID
- P04629
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1229z | Mouse Anti-NTRK1 Recombinant Antibody (clone 18B6) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| MRO-1530-CN | Recombinant Rabbit Anti-NTRK1 Monoclonal Antibody (CBACN-560) | WB, IF, IHC, IP, FC | Rabbit IgG |
| HPAB-0659-YJ | Mouse Anti-NTRK1 Recombinant Antibody (clone 5C3) | Agonist, IHC, IF, Inhib | Mouse IgG2a, κ |
| HPAB-0660-YJ | Human Anti-NTRK1 Recombinant Antibody (clone ch5C3) | Agonist, IHC, IF, Inhib | Chimeric (mouse/human) IgG1, κ |
| ZG-0091U | Rabbit Anti-NTRK1 Recombinant Antibody (clone 2A5) | ELISA, WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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