This monoclonal antibody against P. aeruginosa exopolysaccharide Psl can be potentially used for preventing and treating P. aeruginosa infections.
Figure 1 Functional activity screening of antibodies derived from phage scFv patient libraries.
In vitro functional screens included OPK assays and cell attachment assays using the lung epithelial cell line A549. R347, an isotype-matched human mAb that does not bind P. aeruginosa antigens, was used as a negative control.
Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening
Figure 2 Psl mAb Cam-003 protects mice against lethal challenge in a P. aeruginosa acute pneumonia model.
Animals were monitored for survival between 72 and 120 h after infection. In all experiments, PBS and R347 served as negative controls. A PBS control was not tested in this experiment because previous results indicated no difference in survival versus mice treated with R347. In its place, we used challenge with PAO1ΔpslA as an additional control. Results are represented as Kaplan-Meier survival curves; differences in survival were calculated by the log-rank test for Cam-003 versus R347.
Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MRO-161MZ | Anti-P. aeruginosa exopolysaccharide Psl Recombinant Antibody (Cam-004) (MRO-161MZ) | ELISA, FC, FuncS | Human antibody |
MRO-163MZ | Anti-P. aeruginosa exopolysaccharide Psl Recombinant Antibody (WapR-001) (MRO-163MZ) | ELISA, FC, FuncS | Human antibody |
MRO-164MZ | Anti-P. aeruginosa exopolysaccharide Psl Recombinant Antibody (WapR-002) (MRO-164MZ) | ELISA, FC, FuncS | Human antibody |
MRO-165MZ | Anti-P. aeruginosa exopolysaccharide Psl Recombinant Antibody (WapR-003) (MRO-165MZ) | ELISA, FC, FuncS | Human antibody |
MRO-166MZ | Anti-P. aeruginosa exopolysaccharide Psl Recombinant Antibody (WapR-0016) (MRO-166MZ) | ELISA, FC, FuncS | Human antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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