Recombinant Mouse Anti-P. vivax P25 Antibody (2A8) (CAT#: PABZ-146)

Recombinant Mouse Antibody (2A8) is capable of binding to P. vivax P25, expressed in Chinese Hamster Ovary cells (CHO). 2A8 binds a vertex of the Pvs25 triangle, making contacts with the B loop and central beta-strands of domain 2 using only its heavy-chain variable domain.


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Figure 1 Monoclonal antibodies 1H10 and 1A5 do not bind in the presence of prebound 2A8.

Figure 1 Monoclonal antibodies 1H10 and 1A5 do not bind in the presence of prebound 2A8.

With Pvs25 immobilized on a Biacore chip, 2A8 was injected at (i) until binding was saturated at (ii), and then the second antibody and 2A8 were injected at (iii) until (iv). Buffer without protein was injected from (ii) to (iii) and from (iv) onward.

Saxena, A. K., Singh, K., Su, H. P., Klein, M. M., Stowers, A. W., Saul, A. J., ... & Garboczi, D. N. (2006). The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms. Nature Structural and Molecular Biology, 13(1), 90.


Specifications

  • Immunogen
  • P. vivax p25-alpha domain containing protein
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • IgG
  • Specificity
  • Tested positive against native P. vivax P25
  • Species Reactivity
  • P. vivax
  • Clone
  • 2A8
  • Applications
  • Block Assay-Dependent
    Neut Assay-Dependent

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • The antibody 2A8 has been reported in applications of Block, Neut. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.

Target

  • Alternative Names
  • p25-alpha domain containing protein; p25

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
PABL-672 Recombinant Mouse Anti-P. vivax P25 protein Antibody (2A8) WB, ELISA, FuncS IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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