Anti-PIK3CA immunotoxin (scFv)-PE (CAT#: AGTO-G056E)

• Host Species
• Mouse

• Species Reactivity
• Human

• Molecule Class
• scFv-PE

• Toxin Description
• Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.

• Applications
• This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.

• Related Disease
• Prostate Cancer

• Alternative Names
• PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; MCM; CWS5; MCAP; PI3K; CLOVE; MCMTC; p110-alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3K-alpha; PI3-kinase p110 subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphoinositide-3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE82

• Gene ID
• 5290

• UniProt ID
• P42336

Select a product category from the dropdown menu below to view related products.