This immunotoxin was achieved by conjugating/fusing the Anti-PIK3CA scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to prostate cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating prostate cancer.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1459z | Mouse Anti-PIK3CA Recombinant Antibody (clone 20G7) | WB, IP, IF, FC, ELISA | Mouse IgG1, κ |
MRO-1221-CN | Recombinant Rabbit Anti-PIK3CA Monoclonal Antibody (SJ0186) | WB, IF, IP | Rabbit IgG |
ZG-0511U | Rabbit Anti-PIK3CA Recombinant Antibody (clone 10E5) | ELISA, WB, IF | Rabbit IgG |
VS3-CJ951 | Mouse Anti-PIK3CA Recombinant Antibody (clone ABT-PI3.H1047R) | WB, IF, IHC-P | Mouse IgG3, κ |
VS3-FY1138 | Recombinant Mouse Anti-PIK3CA Antibody (clone 3C1-6F9-6C4) | IHC-P | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2707 | Hi-Affi™ Recombinant Rabbit Anti-PIK3CA Monoclonal Antibody (DS2707AB) | ELISA, IHC-P, WB | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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