Afuco™ Anti-Human PSEN1 ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-686CL
Anti-PSEN1 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. Anti-Presenilin 1 antibody targets Pren, which is expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes, may be used to treat for Alzheimer's Disease, cardiomyopathy dilated type 3, acne inversa familial type 3 (ACNIF3).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to the Golgi apparatus & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67496/1462_C6_5_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity with a granular pattern in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_4_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30760/83531_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000080815-PSEN1/subcellular
❮
❯
Specifications
- Host Species
- Rabbit
- Derivation
- Rabbit
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Alzheimer's Disease
Product Property
- Purity
- >95% as judged by SDS-polyacrylamide gel electrophoresis
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
- Alternative Names
- PSEN1; presenilin 1; AD3; FAD; PS1; PS-1; S182; presenilin-1
- Gene ID
- 5663
- UniProt ID
- A0A024R6A3
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for AFC-686CL. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PSEN1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1791z | Mouse Anti-PSEN1 Recombinant Antibody (clone 35G2) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| MOB-1686CT | Recombinant Mouse anti-Human PSEN1 Monoclonal antibody (45-5D4) | IP, WB | |
| VS3-FY1204 | Recombinant Rabbit Anti-PSEN1 Antibody (clone R05-4D4) | WB, ICC, IF, IP | Rabbit IgG |
| VS3-XY3477 | Rabbit Anti-PSEN1 Recombinant Antibody (clone R01-3J6) | WB, FC | Rabbit IgG |
| VS3-WK1980 | Rabbit Anti-PSEN1 (pS310) Recombinant Antibody (clone R07-6E3) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0001MZ | Recombinant Chicken Anti-PSEN1 IgY | N/A | Chicken antibody |
| BRD-1139MZ | Chicken Anti-Presenilin 1 Polyclonal IgY | WB, ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2883 | Hi-Affi™ Recombinant Rabbit Anti-PSEN1 Monoclonal Antibody (DS2883AB) | WB, IP, ICC, FC, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1278 | AbPlus™ Anti-PSEN1 Magnetic Beads (VS-0724-YC1278) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY407 | Mouse Anti-NHP PSEN1 Recombinant Antibody (clone APS 18) | WB, IHC, ICC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1771 | Anti-PSEN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5764 | Anti-Mouse PSEN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5763 | Anti-Human PSEN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC91 | Recombinant Anti-PSEN1 Vesicular Antibody, EV Displayed (VS-0425-YC91) | ELISA, FC, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: FC, IHC, Cyt, FuncS
-2.png)
Application: WB, ELISA, FuncS
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
