Anti-PSMA Antibody-Cytokine Fusion Protein, IgG (2C9)-IL2 (CAT#: ACFP-SH007)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PSMA IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PSMA as well as the biological activity of IL2. This antibody-cytokine fusion protein is an C-terminus interleukin-2 (IL2)-fused immunocytokine, exhibited enhanced cytotoxic activity against PSMA-expressing prostate cancer cells in the presence of PBMCs. It has a therapeutic potential for prostate cancer by stimulating lymphocyte-mediated antitumor cytotoxicity. This immunocytokine was designed for treating prostate cancer.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Kidney
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Figure 2 Prostate
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
Specifications
- Target
- PSMA
- Molecule Class
- IgG1-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- 2C9
- Related Disease
- prostate cancer
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase
- Gene ID
- 2346
- UniProt ID
- Q04609
Downloads
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See other products for "FOLH1"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1169z-S(P) | Recombinant Anti-Human FOLH1 Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| HPAB-0656-CN-S(P) | Mouse Anti-FOLH1 Recombinant Antibody; scFv Fragment (HPAB-0656-CN-S(P)) | WB, IF, FC | Mouse scFv |
| HPAB-1248WJ-S(P) | Human Anti-FOLH1 Recombinant Antibody (clone 3D8); scFv Fragment | ELISA | Human scFv |
| HPAB-1249WJ-S(P) | Human Anti-FOLH1 Recombinant Antibody (clone 4D4); scFv Fragment | ELISA | Human scFv |
| HPAB-1250WJ-S(P) | Human Anti-FOLH1 Recombinant Antibody (clone 3E11); scFv Fragment | ELISA | Human scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-066 | Recombinant Anti-Human FOLH1 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-277CT | Anti-Human PSMA Therapeutic Single Domain Single Domain Antibody (C3) | ELISA | Single domain antibody |
| HPAB-M0386-YC | Recombinant Camelid Anti-FOLH1 Single Domain Antibody (M/YC-1) | ELISA | Camelid VHH |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-018 | Anti-Human PMSA Recombinant Antibody (Capromab Pendetide) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-274CT | Mouse Anti-FOLH1 Recombinant Antibody (TAB-274CT) | FC, IA, IHC, Inhib, IB, IF, WB, ELISA | Mouse IgG2a |
| TAB-275CT | Mouse Anti-FOLH1 Recombinant Antibody (TAB-275CT) | ICC, FC, Block, IB, IF, IHC, Inhib, WB, ELISA | Mouse IgG1 |
| TAB-276CT | Mouse Anti-FOLH1 Recombinant Antibody (TAB-276CT) | IB, FC, IF, Inhib, WB, ELISA, IHC | Mouse IgG2b |
| TAB-280CT-F(E) | Anti-Human PSMA Recombinant Antibody Fab Fragment (PSf34.1) | ELISA, FC, BL |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G029E | Anti-FOLH1 immunotoxin D7 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G029D | Anti-FOLH1 immunotoxin D7 (scFv)-DT | Cytotoxicity assay, Function study |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0336MZ | Recombinant Mouse Anti-Human FOLH1 Antibody (clone 4F7) | IHC | Mouse antibody |
| HPAB-1708-FY | Human Anti-FOLH1 Recombinant Antibody (HPAB-1708-FY) | Cyt | Human IgG |
| HPAB-1710-FY | Human Anti-FOLH1 Recombinant Antibody (HPAB-1710-FY) | Cyt | Human IgG |
| HPAB-J0213-YC | Mouse Anti-FOLH1 Recombinant Antibody (HPAB-J0213-YC) | ELISA, IHC (0.3µg/mL), FuncS | Mouse IgG |
| HPAB-J0214-YC | Mouse Anti-FOLH1 Recombinant Antibody (HPAB-J0214-YC) | ELISA, IHC (0.3µg/mL) | Mouse IgG |
MHC Tetramer for Cancer
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1332 | Hi-Affi™ Rabbit Anti-FOLH1 Recombinant Antibody (clone DS1332AB) | IHC-P | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0656-CN-F(E) | Mouse Anti-FOLH1 Recombinant Antibody; Fab Fragment (HPAB-0656-CN-F(E)) | WB, IF, FC | Mouse Fab |
| HPAB-0184CQ-F(E) | Human Anti-FOLH1 Recombinant Antibody (clone 2A10); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0185CQ-F(E) | Human Anti-FOLH1 Recombinant Antibody (clone YC058); Fab Fragment | FC, IHC | Human Fab |
| HPAB-M0092-YC-F(E) | Mouse Anti-FOLH1 Recombinant Antibody (clone 10B3); Fab Fragment | FC | Mouse Fab |
| HPAB-M0093-YC-F(E) | Human Anti-FOLH1 Recombinant Antibody (clone h10B3); Fab Fragment | FC | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-018 | Afuco™ Anti-FOLH1 ADCC Recombinant Antibody (Capromab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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