Mouse Anti-RSPO3 Recombinant Antibody (clone 131R003) (CAT#: HPAB-0038CQ)
131R003 is specific inhibitors of RSPO3 and is capable of reducing and blocking RSPO3-induced β-catenin signaling.
Specific Inquiry
Inhib
Figure 1 Affinity-matured 131R003 antibody variants inhibit B-catenin signaling induced by RSPO3 and WNT3A.
A TOPflash luciferase reporter assay was used to measure B-catenin signaling in HEK-293 cells after exposure to a combination of WNT3a and RSPO3 and in the presence of increasing concentrations of anti-RSPO3 antibodies (131R003 (-▲-), 131R003CDR1 variant (-■-), or 131R003 CDR3 variant (-●-)). Antibodies were used as 5-fold serial dilutions from 20 μg/mL to 0.006 μg/mL. Controls included exposure to control medium (no WNT3a and no RSPO)/cells only (-△-), a control antibody (-▼-), WNT3a alone (-♦-), or a combination of WNT3a and RSPO3 in the absence of anti body (-□-).
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2, κ
- Specificity
- Human RSPO3
- Species Reactivity
- Human
- Clone
- 131R003
- Applications
- ELISA, Inhib
- Related Disease
- Non-small cell lung tumor
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Inhibition. Please see the Published Data for further information.
Target
- Alternative Names
- RSPO3; R-spondin 3; PWTSR; THSD2; CRISTIN1; R-spondin-3; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain containing 2; thrombospondin type-1 domain-containing protein 2
- Gene ID
- 84870
- UniProt ID
- Q9BXY4
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 131R003"
See other products for "RSPO3"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2146-VHH | Recombinant Anti-Human RSPO3 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-350CT | Mouse Anti-RSPO3 Recombinant Antibody (TAB-350CT) | WB, ELISA, Neut, FC, IHC, IP | Mouse IgG |
| TAB-353CT | Mouse Anti-RSPO3 Recombinant Antibody (TAB-353CT) | WB, ELISA, Neut, FC, IHC, IP | Mouse IgG |
| TAB-354CT | Mouse Anti-RSPO3 Recombinant Antibody (TAB-354CT) | WB, ELISA, Neut, FC, IHC, IP | Mouse IgG |
| TAB-355CT | Mouse Anti-RSPO3 Recombinant Antibody (TAB-355CT) | WB, ELISA, Neut, FC, IHC, IP | Mouse IgG |
| TAB-356CT | Mouse Anti-RSPO3 Recombinant Antibody (TAB-356CT) | WB, ELISA, Neut, FC, IHC, IP | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-351CT | Humanized Anti-RSPO3 Recombinant Antibody (TAB-351CT) | WB, ELISA, Neut, FC, IHC, IP | Humanized IgG |
| TAB-351CT-S(P) | Humanized Anti-RSPO3 Recombinant Antibody; scFv Fragment (TAB-351CT-S(P)) | WB, ELISA, Neut, FC, IHC, IP | Humanized scFv |
| TAB-351CT-F(E) | Humanized Anti-RSPO3 Recombinant Antibody; Fab Fragment (TAB-351CT-F(E)) | WB, ELISA, Neut, FC, IHC, IP | Humanized Fab |
| TAB-449CQ | Anti-Human RSPO3 Recombinant Antibody (Rosmantuzumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0036CQ-S(P) | Human Anti-RSPO3 Recombinant Antibody (clone h131R008); scFv Fragment | ELISA, Inhib | Humanized scFv |
| HPAB-0037CQ-S(P) | Human Anti-RSPO3 Recombinant Antibody (clone h131R007); scFv Fragment | ELISA, Inhib | Humanized scFv |
| HPAB-0038CQ-S(P) | Mouse Anti-RSPO3 Recombinant Antibody (clone 131R003); scFv Fragment | ELISA, Inhib | Mouse scFv |
| HPAB-M0618-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); scFv Fragment | ELISA | Rat scFv |
| HPAB-M0619-YC-S(P) | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); scFv Fragment | ELISA | Rat scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0618-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6) | ELISA | Rat IgG2a |
| HPAB-M0619-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10) | ELISA | Rat IgG2 |
| HPAB-M0620-YC | Rat Anti-RSPO3 Recombinant Antibody (clone 15F3) | ELISA | Rat IgG2 |
| HPAB-M0621-YC | Human Anti-RSPO3 Recombinant Antibody (clone hu4A6.L4H2) | ELISA, FuncS | Human IgG1 |
| HPAB-M0622-YC | Human Anti-RSPO3 Recombinant Antibody (clone hu11C10.L5H2) | ELISA, FuncS | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0618-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 4A6); Fab Fragment | ELISA | Rat Fab |
| HPAB-M0619-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 11C10); Fab Fragment | ELISA | Rat Fab |
| HPAB-M0620-YC-F(E) | Rat Anti-RSPO3 Recombinant Antibody (clone 15F3); Fab Fragment | ELISA | Rat Fab |
| HPAB-M0621-YC-F(E) | Human Anti-RSPO3 Recombinant Antibody (clone hu4A6.L4H2); Fab Fragment | ELISA, FuncS | Human Fab |
| HPAB-0539-FY-F(E) | Mouse Anti-RSPO3 Recombinant Antibody; Fab Fragment (HPAB-0539-FY-F(E)) | ELISA | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-449CQ | Afuco™ Anti-RSPO3 ADCC Recombinant Antibody (Rosmantuzumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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