This monoclonal antibody which binds to the FbsA protein of Streptococcus agalactia may be useful in the treatment and protection against infections from S. agalactiae.
Figure 1 Effect of mAbs, directed against the repeat region of FbsA, on the interaction of S agalactiae 6313 or FbsA with human Fbg.
Concentration-dependent binding of the anti-FbsA mAbs 5H2 (▪) and 2B1 (⋄) to FbsA. Microtiter wells were coated overnight with 500 ng FbsA in 50 mM sodium carbonate, pH 9.5. The wells were treated for 1 hour at 22°C with 200 μL PBS containing 2% bovine serum albumin (BSA) and washed 5 times with PBS with 0.1% vol/vol Tween 20 (PBST). The plates were incubated with increasing amounts of mAbs 5H2 or 2B1 and the binding of each antibody was detected by incubating the wells with a 1:1000 dilution of rabbit antimouse peroxidase-conjugated polyclonal antibody. After washing, binding was quantitated using the substrate o-phenylenediamine dihydrochloride and measuring the absorbance at 490 nm.
FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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