This product is a recombinant human anti-SARS-CoV monoclonal antibody. CR3014 isolated from a phage display library specifically binds to spike receptor binding domain associated with SARS-CoV and can be potentially used in the diagnosis and treatment studies of SARS-CoV infection.
Figure 1 Neutralization of Wild-Type SARS-CoV and a CR3014- Neutralization Escape Variant (E6) with mAbs CR3014 and CR3022 Individually and in Combination.
Neutralization of 100 TCID₅₀ of each virus was performed in octuplicate.
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants
Figure 2 Binding of mAbs CR3014 and CR3022 to Recombinant WildType and P462L-Substituted S318–510 Fragments Analyzed by ELISA Bars represent the means 6 standard deviation.
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants
Figure 3 Competition ELISA on Immobilized S318–510.
Binding of biotinylated CR3022 was analyzed in the presence of competitor CR3014 (open circles), CR3022 (closed circles), and control mAb (open squares). Binding is expressed as percentage of binding without competitor.
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants
Figure 4 Binding of the IgGs to SARS-CoV-infected Vero cells.
Immunofluorescent staining with IgG CR3014, or negative control IgG (D) is shown.
Molecular and Biological Characterization of Human Monoclonal Antibodies Binding to the Spike and Nucleocapsid Proteins of Severe Acute Respiratory Syndrome Coronavirus
Figure 5 Inhibition of the interaction of S565 with Vero cells by human IgG measured by fluorescence-activated cell sorting.
Vero cells were incubated with S-protein-derived fragment S565 in the absence (thin line) or presence (solid line) of IgG CR3014. The dotted line represents the negative control (irrelevant myc-tagged protein).
Molecular and Biological Characterization of Human Monoclonal Antibodies Binding to the Spike and Nucleocapsid Proteins of Severe Acute Respiratory Syndrome Coronavirus
Figure 6 SARS-CoV neutralizing activity of scFv and IgGs. Neutralization is shown as percentage.
Molecular and Biological Characterization of Human Monoclonal Antibodies Binding to the Spike and Nucleocapsid Proteins of Severe Acute Respiratory Syndrome Coronavirus
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-610LC | Human Anti-SARS-CoV S Recombinant Antibody (MRO-610LC) | ELISA, Neut | Human IgG1, κ |
MRO-611LC | Human Anti-SARS-CoV S Recombinant Antibody (MRO-611LC) | ELISA | Human IgG1, κ |
MRO-612LC | Human Anti-SARS-CoV S Recombinant Antibody (MRO-612LC) | ELISA | Human IgG1, κ |
MRO-613LC | Human Anti-SARS-CoV S Recombinant Antibody (MRO-613LC) | ELISA | Human IgG1, κ |
MRO-614LC | Human Anti-SARS-CoV S Recombinant Antibody (MRO-614LC) | ELISA | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-653LC | Mouse Anti-SARS-CoV S Recombinant Antibody (MRO-653LC) | ELISA | Mouse antibody |
MRO-653LC-F(E) | Mouse Anti-SARS-CoV S Recombinant Antibody; Fab Fragment (MRO-653LC-F(E)) | ELISA | Mouse Fab |
MRO-654LC-F(E) | Mouse Anti-SARS-CoV S Recombinant Antibody; Fab Fragment (MRO-654LC-F(E)) | ELISA | Mouse Fab |
MRO-655LC-F(E) | Anti-SARS-CoV S Recombinant Antibody Fab Fragment (S-9-11) | ELISA | Mouse antibody |
MRO-656LC-F(E) | Anti-SARS-CoV S Recombinant Antibody Fab Fragment (N-176-15) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-1139CQ | Recombinant Human Anti-SARS-CoV S Antibody (m396) | ELISA | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1337WJ | Human Anti-SARS-CoV S Recombinant Antibody (HPAB-1337WJ) | ELISA, FC, WB, IHC, IP | Human IgG2 |
HPAB-1338WJ | Human Anti-SARS-CoV S Recombinant Antibody (HPAB-1338WJ) | ELISA, FC, WB, IHC, IP | Human IgG2 |
HPAB-1339WJ | Human Anti-SARS-CoV S Recombinant Antibody (HPAB-1339WJ) | ELISA, FC, WB, IHC, IP | Human IgG2 |
HPAB-1340WJ | Human Anti-SARS-CoV S Recombinant Antibody (HPAB-1340WJ) | ELISA, FC, WB, IHC, IP | Human IgG2 |
HPAB-1341WJ | Human Anti-SARS-CoV S Recombinant Antibody (clone 68) | ELISA, WB | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1337WJ-F(E) | Human Anti-SARS-CoV S Recombinant Antibody; Fab Fragment (HPAB-1337WJ-F(E)) | ELISA, FC, WB, IHC, IP | Human Fab |
HPAB-1338WJ-F(E) | Human Anti-SARS-CoV S Recombinant Antibody; Fab Fragment (HPAB-1338WJ-F(E)) | ELISA, FC, WB, IHC, IP | Human Fab |
HPAB-1339WJ-F(E) | Human Anti-SARS-CoV S Recombinant Antibody; Fab Fragment (HPAB-1339WJ-F(E)) | ELISA, FC, WB, IHC, IP | Human Fab |
HPAB-1340WJ-F(E) | Human Anti-SARS-CoV S Recombinant Antibody; Fab Fragment (HPAB-1340WJ-F(E)) | ELISA, FC, WB, IHC, IP | Human Fab |
HPAB-1341WJ-F(E) | Human Anti-SARS-CoV S Recombinant Antibody (clone 68); Fab Fragment | ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1342WJ-S(P) | Human Anti-SARS-CoV S Recombinant Antibody (clone S228); scFv Fragment | ELISA, Neut | Human scFv |
HPAB-1343WJ-S(P) | Human Anti-SARS-CoV S Recombinant Antibody (clone S217); scFv Fragment | ELISA, Neut | Human scFv |
HPAB-1344WJ-S(P) | Human Anti-SARS-CoV S Recombinant Antibody (clone S222); scFv Fragment | ELISA, Neut | Human scFv |
HPAB-1345WJ-S(P) | Human Anti-SARS-CoV S Recombinant Antibody (clone S223); scFv Fragment | ELISA, Neut | Human scFv |
HPAB-1346WJ-S(P) | Human Anti-SARS-CoV S Recombinant Antibody (clone S225); scFv Fragment | ELISA, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-474CQ | Camelid Anti-SARS-CoV S Recombinant Single Domain Antibody (clone VHH-44) | Neut | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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