Anti-SARS-CoV S Therapeutic Antibody (CR3022) (CAT#: MRO-1214LC)

This product is a recombinant human anti-SARS-CoV monoclonal antibody. CR3022 specifically binds to spike receptor binding domain associated with SARS-CoV and can be potentially used in the diagnosis and treatment of SARS-CoV infection.

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ELISA

Figure 1. Competition ELISA on Immobilized S318–510.

Binding of biotinylated CR3022 was analyzed in thepresence of competitor CR3014 (open circles), CR3022 (closed circles),and control mAb (open squares). Binding is expressed as percentage ofbinding without competitor.

Ter Meulen, J., Van Den Brink, E. N., Poon, L. L., Marissen, W. E., Leung, C. S., Cox, F., ... & Preiser, W. (2006). Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants. PLoS medicine, 3(7), e237.

Neut

Figure 1 Neutralization of Wild-Type SARS-CoV and a CR3014-Neutralization Escape Variant (E6) with mAbs CR3014 and CR3022 Individually and in Combination.

Neutralization of 100 TCID ₅₀ of each virus was performed in octuplicate.

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

ELISA

Figure 2 Binding of mAbs CR3014 and CR3022 to Recombinant Wild-Type and P462L-Substituted S318–510 Fragments Analyzed by ELISA.

Bars represent the means ± standard deviation.

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

ELISA

Figure 3 Competition ELISA on Immobilized S318–510.

Binding of biotinylated CR3022 was analyzed in the presence of competitor CR3014 (open circles), CR3022 (closed circles), and control mAb (open squares). Binding is expressed as percentage of binding without competitor.

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants


Specifications

  • Host Species
  • Human
  • Derivation
  • Phage display library
  • Type
  • Human antibody
  • Specificity
  • SARS-CoV
  • Clone
  • CR3022
  • Applications
  • Neut, ELISA
  • Related Disease
  • SARS-CoV infection

Applications

  • Application Notes
  • The antibody has been reported in applications of Neutralization, Enzyme-linked Immunosorbent Assay.
    Neut: 60 μg/ml

Target

  • Alternative Names
  • SARS coronavirus; SARS-CoV; SARS coronavirus spike protein; SARS-CoV S

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "SARS-CoV S"


For research use only. Not intended for any clinical use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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