Anti-Human SHH Recombinant Antibody (MEDI-5304) (CAT#: TAB-566CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human SHH. MEDI-5304 is the first fully human hedgehog antibody which inhibited transcription of hedgehog target genes and osteoblast differentiation of C3H10T1/2 cells. MEDI-5304 represents a potent dual hedgehog inhibitor suitable for continued development to evaluate efficacy and safety in human patients with tumors harboring elevated levels of SHH or IHH.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (EFO-21, GAMG, OE19, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164690-SHH/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164690-SHH/subcellular
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- Inhib
- Related Disease
- Tumors
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- 4 °C, -20°C if preferred
Applications
- Application Notes
- This antibody has been tested for use in Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- SHH; sonic hedgehog; TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; sonic hedgehog protein; sonic hedgehog homolog
- Gene ID
- 6469
- UniProt ID
- Q15465
Related Resources
JAK-STAT Signaling Pathway
Pancreatic Cancer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-902-S(P) | Recombinant Human Anti-human SHH Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| HPAB-0710-CN-S(P) | Human Anti-SHH Recombinant Antibody (clone 3H8); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0711-CN-S(P) | Human Anti-SHH Recombinant Antibody (clone 6D7OP); scFv Fragment | ELISA, FC, Neut | Human scFv |
| HPAB-0712-CN-S(P) | Human Anti-SHH Recombinant Antibody (clone 3H8OP); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-N0236-YC-S(P) | Mouse Anti-SHH Recombinant Antibody; scFv Fragment (HPAB-N0236-YC-S(P)) | ELISA, FC, WB, FuncS | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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