Afuco™ Anti-Human SIGLEC15 ADCC Recombinant Antibody (AB-25E9), ADCC Enhanced (CAT#: AFC-546CL)
Anti-SIGLEC15 ADCC Enhanced Antibody (AB-25E9) is an ADCC enhanced antibody produced by our Afuco™ platform. AB-25E9 is a humanized IgG2 that inhibits the function of Siglec-15 and has tremendous potential as a novel antiresorptive for the treatment of patients with acute bone loss.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53509/1201_B2_5_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53509/1201_B2_5_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197046-SIGLEC15/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197046-SIGLEC15/subcellular
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Osteoporosis
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
- Alternative Names
- SIGLEC15; sialic acid binding Ig-like lectin 15; CD33L3; HsT1361; SIGLEC-15; sialic acid-binding Ig-like lectin 15; CD33 antigen-like 3; CD33 molecule-like 3
- Gene ID
- 284266
- UniProt ID
- Q6ZMC9
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Non-Human Primate (NHP) Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-904-F(E) | Recombinant Anti-human SIGLEC15 Antibody Fab Fragment | IF, Neut, FuncS | Fab |
| MHH-904-F(E) | Recombinant Human Anti-human SIGLEC15 Antibody Fab Fragment | IF, FACS, FuncS | Fab |
| HPAB-AP449-YC-F(E) | Rat Anti-SIGLEC15 Recombinant Antibody (clone 24A3); Fab Fragment | Inhib, FuncS | Rat Fab |
| HPAB-AP450-YC-F(E) | Human Anti-SIGLEC15 Recombinant Antibody (clone ch24A3); Fab Fragment | Inhib, FuncS | Chimeric (rat/human) Fab |
| HPAB-AP451-YC-F(E) | Human Anti-SIGLEC15 Recombinant Antibody (clone h24A3-H2/L1); Fab Fragment | Inhib, FuncS | Humanized (rat/human) Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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