Human Anti-SIRPA Recombinant Antibody (clone 29-AM4-5) (CAT#: HPAB-0025-LSX)

Recombinant monoclonal antibody to SIRPαV1 and V2. Clone 29-AM4-5 is a humanized antibody that can be potentially used in the treatment of Acute myeloid leukemia (AML).


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Inhib

Figure 1 The binding inhibition by three anti-SIRPa antibody format compounds (AM3-35, AM4-5 and AM4-1) of binding between CD47-Fc and hSIRPα V2 expressed on mouse macrophages.

Figure 1 The binding inhibition by three anti-SIRPa antibody format compounds (AM3-35, AM4-5 and AM4-1) of binding between CD47-Fc and hSIRPα V2 expressed on mouse macrophages.

Inhib

Figure 2 Inhibition of hCD47-Fc binding to human SIRPα-V2 expressed on the surface of CHO cells in A) the absence or presence of two concentrations of anti-SIRPα Ab AM4-5, and, B).

Figure 2 Inhibition of hCD47-Fc binding to human SIRPα-V2 expressed on the surface of CHO cells in A) the absence or presence of two concentrations of anti-SIRPα Ab AM4-5, and, B).

Escalating concentrations of five anti-SIRPα Fab made by affinity maturation of AM4-5.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized IgG
  • Specificity
  • Human SIRPα
  • Species Reactivity
  • Human, Mouse
  • Clone
  • 29-AM4-5
  • Applications
  • ELISA, Inhib
  • Related Disease
  • Acute myeloid leukemia

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Inhibition.

Target

  • Alternative Names
  • SIRPA; signal-regulatory protein alpha; BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; tyrosine-protein phosphatase non-receptor type substrate 1; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-based activation motifs

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 29-AM4-5"

See other products for "Sirpa"

Single-domain Antibody

CAT Product Name Application Type
NAB-1201-VHH Recombinant Anti-Mouse Sirpa VHH Single Domain Antibody IP, FC, ChiP, Neut Llama VHH

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0465MZ Chicken Anti-PTPNS1 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1970CQ Recombinant Rat Anti-Sirpa Antibody (P84) FC, BL, IF, IHC, IP IgG1, κ

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1971CQ Recombinant Mouse Anti-Sirpa Antibody (CBL650) WB, FC, CyTOF, Neut IgG2b

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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