Recombinant Anti-human SNCA Intrabody [Tat] (CAT#: IAB-B031(T))
Recombinant anti-SNCA intrabody in fusion with HIV Tat works within cells to bind human monomeric wild-type SNCA, expressed in E. coli cells. The intrabody stabilizes detergent-soluble monomeric syn and inhibits the formation of detergent-insoluble high-molecular-weight syn species. In addition, the intrabody ameliorates the decreased cell adhesion that characterizes the syn-overexpressing cells. Anti-SNCA intrabodies may represent novel molecular therapeutics for synucleinopathies, with implications for other neurodegenerative disorders caused by misfolded accumulated proteins.
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Normal Tissue
RNA Expression
Figure 1 High expression in cerebral cortex
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
Figure 2 Colon
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
Figure 4 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
Figure 5 Bone marrow
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
Specifications
- Immunogen
- human synuclein, alpha (non A4 component of amyloid precursor)
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Products can be used for: Enzyme-linked Immunosorbent Assay; Immunofluorescence; Neutralization; Functional studies
Product Property
- Purity
- 95% by HPLC
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
- Gene ID
- 6622
- UniProt ID
- P37840
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1365z | Mouse Anti-SNCA Recombinant Antibody (clone 8F8) | ELISA, FC, ICC, IF, WB | Mouse IgG1 |
| HPAB-N0389-YC | Human Anti-SNCA Recombinant Antibody (HPAB-N0389-YC) | ELISA, IP, FuncS | Human IgG |
| HPAB-N0390-YC | Mouse Anti-SNCA Recombinant Antibody (HPAB-N0390-YC) | ELISA, IP, FuncS | Mouse IgG |
| VS-0323-CJ51 | Human Anti-SNCA Recombinant Antibody (clone pF) | ELISA, WB, IF, IHC, DB, Inhib, Cyt, FuncS | Human IgG |
| VS-0323-CJ52 | Human Anti-SNCA Recombinant Antibody (clone Pc) | ELISA, WB, IF, IHC, DB, Inhib, Cyt, FuncS | Human IgG |
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