Anti-Human SOST Single Domain Antibody (TAB-392CT), Research Grade Biosimilar
CAT#: TAB-392CT
Recombinant single domain antibody that specifically binds to sclerostin. The antibody can be potentially used for the prevention and treatment of bone diseases and disorders.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (HaCaT, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167941-SOST
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Specifications
- Immunogen
- Recombinant human sclerostin
- Host Species
- Llama
- Derivation
- Llama immuniezd library
- Type
- Single domain antibody
- Specificity
- Human
- Species Reactivity
- Human, Mouse
- Clone
- TAB-392CT
- Applications
- Used for immunoassay techniques such as: Western Blot; ELSA; Flow Cytometry
- Related Disease
- Multiple myeloma, osteoporosis, osteopenia, Paget's Disease, bone fracture, bone loss.
Target
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Customer Review
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Excellent for Osteoporosis Research
I have been using the Anti-Human SOST Antibody for my osteoporosis research, focusing on the Wnt signaling pathway. The antibody's sensitivity and specificity have provided consistent results, enabling a deeper understanding of sclerostin's role in bone formation. The impeccable batch-to-batch consistency boosts my confidence in long-term projects.
Reliable in Bone Disease Studies
As someone deeply engaged in bone metabolism research, this antibody has been an essential tool. It offers remarkable stability, which has made analyses involving sclerostin efficient and reproducible. Its application in ELISA and Western Blot is flawless and has significantly advanced our understanding of related diseases.
Consistent and Sensitive
The sensitivity of this antibody in detecting sclerostin is unbeatable, making it a staple in my lab. Creative Biolabs' innovative production techniques ensure each batch matches the high standards needed for groundbreaking research.
Q&As
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What research applications does the Anti-Human SOST Antibody support?
A: The Anti-Human SOST Single Domain Antibody is primarily used in osteoporosis and related bone disease studies, as sclerostin is a negative regulator of bone formation. This antibody is employed in immunoassay techniques such as Western Blot, ELISA, and Flow Cytometry to identify and quantify SOST protein levels in biological samples, furthering our understanding of bone metabolism and potential therapeutic avenues.
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How does sclerostin contribute to disease processes?
A: Sclerostin, encoded by the SOST gene, inhibits the Wnt signaling pathway, which is vital for bone formation. Reduced activity or expression of sclerostin leads to increased bone mass, whereas its overexpression can contribute to conditions like osteoporosis by suppressing bone formation. Anti-sclerostin antibodies, by neutralizing its activity, can creatively modulate these pathways for therapeutic benefits, especially in degenerative bone diseases.
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What diseases can be further studied using the anti-SOST antibody?
A: Aside from osteoporosis, the antibody is instrumental in studying multiple myeloma, Paget's disease, osteopenia, and other metabolic bone disorders. Disruptions in sclerostin levels are significant in these diseases, making this antibody a valuable tool for research and potential therapeutic intervention studies.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-558CL | Afuco™ Anti-SOST Recombinant Antibody (AFC-558CL), ADCC Enhanced | ELISA, WB | Humanized IgG1 |
| AFC-TAB-116 | Afuco™ Anti-SOST Recombinant Antibody (AFC-TAB-116), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | Human IgG1, κ |
| AFC-TAB-115 | Afuco™ Anti-SOST ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-115) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-384CT | Llama Anti-SOST Recombinant Antibody (TAB-384CT) | WB, ELSA, FC | Llama VHH |
| TAB-385CT | Anti-Human SOST Single Domain Antibody (TAB-385CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-386CT | Anti-Human SOST Single Domain Antibody (TAB-386CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-387CT | Anti-Human SOST Single Domain Antibody (TAB-387CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-388CT | Anti-Human SOST Single Domain Antibody (TAB-388CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-411CT-S(P) | Humanized Anti-SOST Recombinant Antibody; scFv Fragment (TAB-411CT-S(P)) | ELISA, Neut | Humanized scFv |
| TAB-412CT-S(P) | Humanized Anti-SOST Recombinant Antibody; scFv Fragment (TAB-412CT-S(P)) | ELISA, Neut | Humanized scFv |
| TAB-411CT-F(E) | Humanized Anti-SOST Recombinant Antibody; Fab Fragment (TAB-411CT-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-412CT-F(E) | Humanized Anti-SOST Recombinant Antibody; Fab Fragment (TAB-412CT-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-413CT-F(E) | Humanized Anti-SOST Recombinant Antibody; Fab Fragment (TAB-413CT-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-393CT-F(E) | Anti-Human SOST Recombinant Antibody Fab Fragment (DM4) | ELISA, Neut | Human antibody |
| TAB-394CT-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (TAB-394CT-F(E)) | ELISA, Neut | Human Fab |
| TAB-395CT-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (TAB-395CT-F(E)) | ELISA, Neut | Human Fab |
| TAB-396CT-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (TAB-396CT-F(E)) | ELISA, Neut | Human Fab |
| TAB-397CT-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (TAB-397CT-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4434 | Hi-Affi™ Recombinant Rabbit Anti-SOST Monoclonal Antibody (SI527DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0342-YC | Human Anti-SOST Recombinant Antibody (HPAB-0342-YC) | Neut, FuncS | Humanized IgG |
| HPAB-0343-YC | Mouse Anti-SOST Recombinant Antibody (HPAB-0343-YC) | FuncS | Mouse IgG |
| HPAB-0344-YC | Human Anti-SOST Recombinant Antibody (HPAB-0344-YC) | ELISA, FuncS | Human IgG2, κ |
| HPAB-0461-CN | Human Anti-SOST Recombinant Antibody (HPAB-0461-CN) | ELISA, Block | Humanized IgG |
| HPAB-0462-CN | Human Anti-SOST Recombinant Antibody (HPAB-0462-CN) | ELISA, Block | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0342-YC-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (HPAB-0342-YC-F(E)) | Neut, FuncS | Humanized Fab |
| HPAB-0343-YC-F(E) | Mouse Anti-SOST Recombinant Antibody; Fab Fragment (HPAB-0343-YC-F(E)) | FuncS | Mouse Fab |
| HPAB-0344-YC-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (HPAB-0344-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-0461-CN-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (HPAB-0461-CN-F(E)) | ELISA, Block | Human Fab |
| HPAB-0462-CN-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (HPAB-0462-CN-F(E)) | ELISA, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0461-CN-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0461-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0462-CN-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0462-CN-S(P)) | ELISA, Block | Humanized scFv |
| HPAB-0463-CN-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0463-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0464-CN-S(P) | Mouse Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0464-CN-S(P)) | ELISA, Block | Mouse scFv |
| HPAB-0467-CN-S(P) | Mouse Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0467-CN-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY246 | AbPlus™ Anti-SOST Magnetic Beads (VS-0424-XY2446) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY180 | Human Anti-SOST scFv-Fc Chimera (VS-0425-FY180) | Inhib, ELISA | Human IgG2, scFv-Fc |
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