Recombinant Rat Anti-Sirpa Antibody (P84) (CAT#: NEUT-1970CQ)

1. Q 1: What are the research applications for the Recombinant Anti-Sirpa Antibody?

   A: The Recombinant Anti-Sirpa Antibody, specifically designed to target mouse SIRPα, is utilized in immunoassay techniques such as Flow Cytometry, Immunofluorescence, and Immunohistochemistry. It's particularly valuable in studying signaling pathways and immune modulation processes, as SIRPα is integral in cell-cell communication, especially involving macrophages and their regulation via the CD47-SIRPα pathway.

2. Q 2: How does targeting SIRPα help in cancer research?

   A: SIRPα and its interaction with CD47 operate as a "don't eat me" signal, which cancer cells exploit to avoid phagocytosis by macrophages. By targeting this pathway with the Anti-Sirpa Antibody, researchers can disrupt the signal, thereby enhancing macrophage-mediated clearance of cancer cells. This approach is central to developing therapies aimed at boosting the immune system's ability to eliminate tumors.

3. Q 3: What makes the Recombinant Anti-Sirpa Antibody unique in its application?

   A: This antibody boasts high specificity and affinity for mouse SIRPα, a feature achieved through its recombinant nature, ensuring superior sensitivity and confirmed specificity in assays. The IgG1, κ subclass adds to its versatility, allowing for high repeatability and excellent batch-to-batch consistency for research continuity and advancement.

View the frequently asked questions answered by Creative Biolabs Support.