Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2) (CAT#: PABW-119)

Figure 1 Fluorescence microscopic images of LS174T cells.

The cells were fixed with 3.7% paraformaldehyde and incubated for 1 hour at room temperature with murine CC49-Cy7, murine CC49 followed by murine CC49-Cy7, HuCC49ΔCH2-Cy7, and murine CC49 followed by HuCC49ΔCH2-Cy7.

Zou, P., Xu, S., Povoski, S. P., Wang, A., Johnson, M. A., Martin Jr, E. W., ... & Sun, D. (2009). Near-infrared fluorescence labeled anti-TAG-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice. Molecular pharmaceutics, 6(2), 428-440.

Figure 2 The relative mean fluorescence intensity in the tumor and liver regions of interest (ROIs) as a function of time after injection of Cy7, excessive murine CC49 plus HuCC49ΔCH2-Cy7, or HuCC49ΔCH2-Cy7.

Zou, P., Xu, S., Povoski, S. P., Wang, A., Johnson, M. A., Martin Jr, E. W., ... & Sun, D. (2009). Near-infrared fluorescence labeled anti-TAG-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice. Molecular pharmaceutics, 6(2), 428-440.

Figure 3 The relative fluorescence intensity of each tissue was labeled near the corresponding tissue.

Representative images of dissected organs of athymic nude mice bearing LS174T xenograft tumor sacrificed 2 hours or 18 hours after intravenous injection of 1 nmol of Cy7, excessive murine CC49 followed by 0.73 nmol HuCC49ΔCH2-Cy7, 0.73 nmol HuCC49ΔCH2-Cy7, or 0.50 nmol non-specific human IgG-Cy7. The relative fluorescence intensity of each tissue was labeled near the corresponding tissue.

Zou, P., Xu, S., Povoski, S. P., Wang, A., Johnson, M. A., Martin Jr, E. W., ... & Sun, D. (2009). Near-infrared fluorescence labeled anti-TAG-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice. Molecular pharmaceutics, 6(2), 428-440.

Figure 4 Tissue-to-heart ratios for the mice sacrificed 2 hours after injection

Zou, P., Xu, S., Povoski, S. P., Wang, A., Johnson, M. A., Martin Jr, E. W., ... & Sun, D. (2009). Near-infrared fluorescence labeled anti-TAG-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice. Molecular pharmaceutics, 6(2), 428-440.

Figure 5 Tissue-to-heart ratios for the mice sacrificed 18 hours after injection

Zou, P., Xu, S., Povoski, S. P., Wang, A., Johnson, M. A., Martin Jr, E. W., ... & Sun, D. (2009). Near-infrared fluorescence labeled anti-TAG-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice. Molecular pharmaceutics, 6(2), 428-440.