Anti-Human TCR Recombinant Antibody (WT31) (CAT#: TAB-549CT)
Recombinant monoclonal antibody specifically binds to human TCR alpha/beta. This antibody can be potentially used in treating T-cell malignancies.
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Inhib
Figure 1 Inhibition of tetramer-binding to T cells by preincubation with anti-CD3 and anti-TCR antibodies.
CTL INFA24 was preincubated with 3-fold increasingconcentrations ranging from 0.07–50 μg/ml of anti-CD3 antibodies, SPV-T3b (○), OKT3 (■), and anti-TCR antibodies WT31 (△) and T10B9 (●) or control IgG (X), followedby incubations with GAM-Ig and HLA-A2/flu tetramer. Left panel: binding intensity (MFI) of anti-CD3 or anti-TCR antibodies or control IgG to CTLINFA24 T cells.
Weder, P., Schumacher, T. N., Spits, H., & Luiten, R. M. (2012). Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes. Results in immunology, 2, 88-96.
Specifications
- Host Species
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- WT31
- Applications
- Inhib
- Related Disease
- Autoimmune Disease, T-cell malignancies
Applications
- Application Notes
- This antibody has been reported for use in Inhibition assay.
Target
- Alternative Names
- TCR; T cell receptor; TCRA; TCRB
Related Resources
Asthma
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Amyotrophic Lateral Sclerosis
Maturity Onset Diabetes of the Young
TCR Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Customer Reviews and Q&As
Customer Review
Q&As
Excellent Research Tool for TCR Studies
I've been using this antibody for T-cell receptor studies, and it has significantly enhanced the sensitivity of my experiments. The specificity is outstanding, and it has been a reliable product over time.
Valuable for Cancer Studies
The Anti-Human TCR Recombinant Antibody has been valuable for cancer research in my lab. Its use in signal transduction studies has opened new directions for our project on cancer biomarkers.
Great Customer Support
Creative Biolabs' customer support has been very helpful whenever I had questions about the product. Their guidance made it easy to integrate the antibody into my existing research framework.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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