Recombinant monoclonal antibody specifically binds to DO-11.10 T-cell receptor. This antibody can be potentially used in treating T-cell malignancies.
Figure 1 Gating of OVA-specific CD4⁺ T cells.
Dead cells were excluded by FVS450 staining. OVA-specific CD4⁺ T cells were gated as CD4⁺ KJ1-26⁺ among live cells.
Ding, Z., Dahlin, J. S., Xu, H., & Heyman, B. (2016). IgE-mediated enhancement of CD4+ T cell responses requires antigen presentation by CD8α− conventional dendritic cells. Scientific reports, 6, 28290.
Figure 2 The other half of each spleen was frozen and spleen sections were stained and analysed by confocal microscopy.
DO11.10 TCR (clone KJ1-26) mAb, red. Images show T cell areas (640 μm × 640 μm) representative of 6 T cell zones from 2 non-consecutive sections per sample in each group. Scale bar represents 100 μm.
Ding, Z., Dahlin, J. S., Xu, H., & Heyman, B. (2016). IgE-mediated enhancement of CD4+ T cell responses requires antigen presentation by CD8α− conventional dendritic cells. Scientific reports, 6, 28290.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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