Human Anti-TFPI Recombinant Antibody (clone mAb 2021); scFv Fragment (CAT#: PSBL-711)
Recombinant Human Antibody (mAb 2021) scFv Fragment is specific to TFPI, expressed in E. coli. This scFv fragment against TFPI was investigated. Binding of this scFv fragment to TFPI effectively prevented inhibition of FVIIa/TF/FXa and improved clot formation in hemophilia blood and plasma.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human smooth muscle
(Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
(Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
(Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
Figure 4 Colon
(Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
(Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
Figure 6 Placenta
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
Specifications
- Immunogen
- Human tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
- Host Species
- Human
- Type
- Human scFv
- Specificity
- Human TFPI
- Species Reactivity
- Human
- Clone
- mAb 2021
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TFPI; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor
- Gene ID
- 7035
- UniProt ID
- P10646
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-734 | Anti-TFPI Recombinant Antibody (Concizumab) | ELISA, IP, FC, FuncS, Neut, IF, WB | IgG4 - kappa |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3547 | Rabbit Anti-TFPI Recombinant Antibody (clone DS3547AB) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0476-CN | Mouse Anti-TFPI Recombinant Antibody (HPAB-0476-CN) | ELISA | Mouse IgG |
| HPAB-0477-CN | Human Anti-TFPI Recombinant Antibody (HPAB-0477-CN) | ELISA, Neut | Chimeric (mouse/human) IgG1, κ |
| HPAB-0478-CN | Human Anti-TFPI Recombinant Antibody (HPAB-0478-CN) | ELISA, Neut | Humanized IgG1, κ |
| HPAB-0479-CN | Human Anti-TFPI Recombinant Antibody (HPAB-0479-CN) | ELISA, Neut | Human IgG |
| HPAB-0480-CN | Human Anti-TFPI Recombinant Antibody (HPAB-0480-CN) | ELISA, Neut | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0476-CN-F(E) | Mouse Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-0476-CN-F(E)) | ELISA | Mouse Fab |
| HPAB-0477-CN-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-0477-CN-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0478-CN-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-0478-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0779-CN-F(E) | Mouse Anti-TFPI Recombinant Antibody (clone 3F18); Fab Fragment | ELISA, Neut | Mouse Fab |
| HPAB-2605LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2605LY-F(E)) | ELISA, WB, FuncS | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-734 | Afuco™ Anti-TFPI ADCC Recombinant Antibody (Concizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2580LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2580LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| HPAB-2581LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2581LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| HPAB-2582LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2582LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| HPAB-0495-YJ-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0495-YJ-S(P)) | ELISA, WB, FuncS | Human scFv |
| HPAB-0496-YJ-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0496-YJ-S(P)) | ELISA, WB, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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