Anti-Human TIM-3 Recombinant Antibody scFv Fragment (mAb15) (CAT#: TAB-666CT-S(P))
Recombinant monoclonal antibody specifically binds to human TIM-3 and inhibits the interaction of TIM-3 and LILRB2 antibodies.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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-1.png)
Figure 1 show graphs demonstrating that TIM-3 inhibition stimulates expression of DC co-stimulatory molecules and cytokine release by DCs.
Following LPS activation, DCs were treated with no antibody, a mIgG1 isotype control, a commercially available anti-TIM-3 antibody (F38-2E2) or antibodies. Co-stimulatory molecules or cytokines were measured on Day 4 post-LPS activation.
-2.png)
Figure 2 show graphs demonstrating release of IL-1β, TNFα and IL-6 from macrophages stimulated by HMGB-1 following treatment with antibodies.
Antibodies were the commercially available anti-TIM-3 antibody, F38-2E2, and anti-TIM-3 antibody mAb15. mIgG1 served as an isotype negative control antibody.
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Figure 3 shows a graph demonstrating a dose curve of release of TNFα from macrophages stimulated by HMGB-1 following treatment with different doses of antibodies.
Antibodies were the commercially available anti-TIM-3 antibody F38-2E2 (circles) and anti-TIM-3 antibody mAb15 (squares).
-4.png)
Figure 4 show graphs demonstrating dose curve of release of IL-1β from macrophages stimulated by LPS following treatment with different doses of antibodies.
Antibodies were the commercially available anti-TIM-3 antibody F38-2E2 (circles), anti-TIM-3 antibody mAb15 (squares) and anti-LILRB2 (clone 287219) (inverted triangles). mIgG1 isotype (diamonds) and no antibody (triangles) served as a negative control. Data were collected at 24 hr, 48 hr, and 3 days post-treatment as indicated.
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Figure 5 shows mixed lymphocyte reaction on day 1 or day 7 following treatment with F38-2E2, mAb15 or an isotype control.
Supernatants were assessed for their expression of IL-1β, TNFα and IFN-γ at the time points indicated.
Specifications
- Immunogen
- Human TIM-3-Fc
- Host Species
- Mouse
- Derivation
- Mouse hybridoma cell line
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- mAb15
- Applications
- ELISA, FC, Inhibit, FuncS
- Related Disease
- Acute Myelocytic Leukemia
Applications
- Application Notes
- The antibody was validated for Function assay. For details, refer to Published Data.
Target
- Alternative Names
- T-cell immunoglobulin and mucin domain containing molecule-3; TIM3; anti-TIM3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibodies
Fab Antibodies
ScFv Antibodies
Human Antibodies
Mouse Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-976 | Recombinant Anti-Tim-3 Antibody | WB, Neut, FuncS | IgG |
| MHH-976 | Recombinant Human Anti-Tim-3 Antibody | ELISA, WB, FuncS | IgG |
| VS-0723-WK188 | Rabbit Anti-TIM3 Recombinant Antibody (VS-0723-WK188) | ELISA, FC | Rabbit IgG |
| VS-0723-WK280 | Rabbit Anti-TIM3 Recombinant Antibody (VS-0723-WK280) | ELISA, FC | Rabbit IgG |
| VS-0723-WK289 | Rabbit Anti-TIM3 Recombinant Antibody (VS-0723-WK289) | ELISA, FC | Rabbit IgG |
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