Human Anti-TIMP1 Recombinant Antibody (clone HuCAL) (CAT#: HPAB-0174-YC)
Tissue inhibitors of metalloproteases (TIMPs) inhibit metalloproteases, a family of endopeptide hydrolases. Metalloproteases are secreted by connective tissue and hematopoietic cells, use Zn2+ or Ca2+ for catalysis, and may be inactivated by metal chelators as well as TIMP molecules. Matrix metalloproteases (MMPs) participate in a variety of biologically important processes, including the degradation of many structural components of tissues, particularly the extracellular matrix (ECM).
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Figure 1 Comparison of monovalent affinities of Fab antibody fragments selected after three rounds of standard panning on β-galactosidase and after RapMAT.
Identical shades of blue indicate antibodies of one sequence group: nonmatured parental antibody and RapMAT-optimized offspring (exemplified by arrows for one group). Horizontal lines represent the median affinity.
Prassler, J., Steidl, S., & Urlinger, S. (2009). In vitro affinity maturation of HuCAL antibodies: complementarity determining region exchange and RapMAT technology. Immunotherapy, 1(4), 571-583.
Figure 2 Monovalent affinities reached in therapeutic antibody projects before and after affinity maturation using the HuCAL GOLD library.
Monovalent affinities reached in therapeutic antibody projects before and after affinity maturation using the HuCAL GOLD library. HuCAL: Human combinatorial antibody library.
Prassler, J., Steidl, S., & Urlinger, S. (2009). In vitro affinity maturation of HuCAL antibodies: complementarity determining region exchange and RapMAT technology. Immunotherapy, 1(4), 571-583.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human TIMP1
- Species Reactivity
- Human
- Clone
- HuCAL
- Applications
- ELISA
- Related Disease
- Liver fibrosis, Alcoholic liver disease, Cardiac fibrosis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-683CT | Anti-Human TIMP-1 Recombinant Antibody (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-683CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-684CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-28) | ELISA, BL | Human antibody |
| TAB-685CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-1) | ELISA, BL | Human antibody |
| TAB-686CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-27) | ELISA, BL | Human antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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