Tissue inhibitors of metalloproteases (TIMPs) inhibit metalloproteases, a family of endopeptide hydrolases. Metalloproteases are secreted by connective tissue and hematopoietic cells, use Zn2+ or Ca2+ for catalysis, and may be inactivated by metal chelators as well as TIMP molecules. Matrix metalloproteases (MMPs) participate in a variety of biologically important processes, including the degradation of many structural components of tissues, particularly the extracellular matrix (ECM).
Figure 1 Comparison of monovalent affinities of Fab antibody fragments selected after three rounds of standard panning on β-galactosidase and after RapMAT.
Identical shades of blue indicate antibodies of one sequence group: nonmatured parental antibody and RapMAT-optimized offspring (exemplified by arrows for one group). Horizontal lines represent the median affinity.
Prassler, J., Steidl, S., & Urlinger, S. (2009). In vitro affinity maturation of HuCAL antibodies: complementarity determining region exchange and RapMAT technology. Immunotherapy, 1(4), 571-583.
Figure 2 Monovalent affinities reached in therapeutic antibody projects before and after affinity maturation using the HuCAL GOLD library.
Monovalent affinities reached in therapeutic antibody projects before and after affinity maturation using the HuCAL GOLD library. HuCAL: Human combinatorial antibody library.
Prassler, J., Steidl, S., & Urlinger, S. (2009). In vitro affinity maturation of HuCAL antibodies: complementarity determining region exchange and RapMAT technology. Immunotherapy, 1(4), 571-583.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
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• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1378z | Mouse Anti-TIMP1 Recombinant Antibody (clone 39D12) | WB, ELISA | Mouse IgG1 |
HPAB-0192-WJ | Human Anti-TIMP1 Recombinant Antibody (HPAB-0192-WJ) | ELISA | Human IgE |
ZG-0125C | Mouse Anti-TIMP1 Recombinant Antibody (clone PT2236) | IHC-P, IF | Mouse IgG |
ZG-0126C | Mouse Anti-TIMP1 Recombinant Antibody (clone ABT-TIMP1) | IHC-P, IF | Mouse IgG |
ZG-0205U | Mouse Anti-TIMP1 Recombinant Antibody (clone 8B4E9) | ELISA, WB, IHC | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-683CT | Anti-Human TIMP-1 Recombinant Antibody (MS-BW-3 ) | ELISA, BL | Human antibody |
TAB-684CT | Anti-Human TIMP-1 Recombinant Antibody (MS-BW-28) | ELISA, BL | Human antibody |
TAB-685CT | Anti-Human TIMP-1 Recombinant Antibody (MS-BW-1) | ELISA, BL | Human antibody |
TAB-686CT | Anti-Human TIMP-1 Recombinant Antibody (MS-BW-27) | ELISA, BL | Human antibody |
TAB-683CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-3 ) | ELISA, BL | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3575 | Rabbit Anti-TIMP1 Recombinant Antibody (clone DS3575AB) | WB | Rabbit IgG |
MOR-4458 | Rabbit Anti-TIMP1 Recombinant Antibody (clone SI552DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC1976 | PE-B7/Human TIMP1 (APFEPLASGIL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0174-YC-S(P) | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL); scFv Fragment | ELISA | Human scFv |
HPAB-0192-WJ-S(P) | Human Anti-TIMP1 Recombinant Antibody; scFv Fragment (HPAB-0192-WJ-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0174-YC-F(E) | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL); Fab Fragment | ELISA | Human Fab |
HPAB-0192-WJ-F(E) | Human Anti-TIMP1 Recombinant Antibody; Fab Fragment (HPAB-0192-WJ-F(E)) | ELISA | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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