Afuco™ Anti-Human TMPRSS4 ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-599CL
Anti-TMPRSS4 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. The anti-ovarian antibodies that bind to Ovr115 are used in treating pancreatic, lung or breast cancer.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows cytoplasmic positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_4_5_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (CAPAN-2, HaCaT, OE19, RPTEC TERT1, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137648-TMPRSS4
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Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
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Boosts Cancer Research Potential
This antibody has greatly enhanced our research capabilities by providing clearer insights into TMPRSS4-related pathways. Its ADCC properties help us explore how immune responses can be manipulated to develop more effective cancer treatments.
Versatile Application in Studies
We've found this antibody very versatile, suitable for a range of assays like ELISA and flow cytometry. Its high purity ensures that our results are consistent and reproducible, which is crucial for validating our experimental findings.
Enhances Immune Research
The ADCC enhancement has transformed how we study immune interactions with cancer cells. This antibody's ability to amplify immune responses helps clarify mechanisms of tumor resistance, guiding our research towards potential immunotherapy strategies.
Q&As
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What is the primary use of the Anti-TMPRSS4 ADCC Enhanced Antibody?
A: This antibody is primarily used in research to study TMPRSS4, a protein associated with pancreatic, lung, and breast cancers. It enhances ADCC (Antibody-Dependent Cellular Cytotoxicity), allowing researchers to explore cancer progression mechanisms and potential therapeutic targets with more precision.
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What makes this antibody different from others?
A: This antibody is part of Creative Biolabs' Hi-Affi™ portfolio, known for enhanced specificity and sensitivity. It features ADCC enhancement, which boosts immune cell activity against cancer cells, thereby providing more accurate data in cancer research settings.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TMPRSS4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-720CT | Human Anti-TMPRSS4 Recombinant Antibody (TAB-720CT) | WB, ELISA | Human antibody |
| TAB-721CT | Human Anti-TMPRSS4 Recombinant Antibody (TAB-721CT) | WB, ELISA | Human antibody |
| TAB-720CT-F(E) | Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (TAB-720CT-F(E)) | WB, ELISA | Human Fab |
| TAB-721CT-F(E) | Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (TAB-721CT-F(E)) | WB, ELISA | Human Fab |
| TAB-722CT-F(E) | Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (TAB-722CT-F(E)) | WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0244-YC | Human Anti-TMPRSS4 Recombinant Antibody (HPAB-J0244-YC) | FC | Human IgG |
| HPAB-J0245-YC | Human Anti-TMPRSS4 Recombinant Antibody (HPAB-J0245-YC) | FC | Human IgG |
| HPAB-J0246-YC | Human Anti-TMPRSS4 Recombinant Antibody (HPAB-J0246-YC) | FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0244-YC-S(P) | Human Anti-TMPRSS4 Recombinant Antibody; scFv Fragment (HPAB-J0244-YC-S(P)) | FC | Human scFv |
| HPAB-J0245-YC-S(P) | Human Anti-TMPRSS4 Recombinant Antibody; scFv Fragment (HPAB-J0245-YC-S(P)) | FC, WB, Inhib | Human scFv |
| HPAB-J0246-YC-S(P) | Human Anti-TMPRSS4 Recombinant Antibody; scFv Fragment (HPAB-J0246-YC-S(P)) | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0244-YC-F(E) | Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (HPAB-J0244-YC-F(E)) | FC | Human Fab |
| HPAB-J0245-YC-F(E) | Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (HPAB-J0245-YC-F(E)) | FC, WB, Inhib | Human Fab |
| HPAB-J0246-YC-F(E) | Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (HPAB-J0246-YC-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC485 | Recombinant Anti-TMPRSS4 Vesicular Antibody, EV Displayed (VS-0425-YC485) | ELISA, FC, Cell-uptake |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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