Anti-TNFRSF12A immunotoxin ITEM-4 (scFv)-Gel
CAT#: AGTO-G061G
This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF12A scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF12A overexpressed tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating malignant melanoma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7853/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7853/21168_B_7_5.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7853/21168_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7853/21168_A_9_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7853/21168_A_4_6.jpg
Normal Tissue
Figure 6 Placenta
Trophoblastic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7853/21168_A_2_7.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7853/21168_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (U-251 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000006327-TNFRSF12A
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- ITEM-4
- Molecule Class
- scFv-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Malignant Melanoma
Target
- Alternative Names
- TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; FN14; CD266; TWEAKR; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14; Gelonin; Gel
- Gene ID
- 51330
- UniProt ID
- Q9NP84
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- CAT
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-218CQ-S(P) | Mouse Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-218CQ-S(P)) | ELISA, FC, IHC | Mouse scFv |
| TAB-222CQ-S(P) | Mouse Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-222CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-223CQ-S(P) | Mouse Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-223CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-224CQ-S(P) | Chicken Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-224CQ-S(P)) | ELISA, FC | Chicken scFv |
| TAB-226CQ-S(P) | Chicken Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-226CQ-S(P)) | ELISA, FC | Chicken scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-219CQ-S(P) | Human Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-219CQ-S(P)) | ELISA, FC, IHC | Humanized scFv |
| TAB-225CQ-S(P) | Human Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-225CQ-S(P)) | ELISA, FC | Humanized scFv |
| TAB-227CQ-S(P) | Human Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-227CQ-S(P)) | ELISA, FC | Humanized scFv |
| TAB-219CQ-F(E) | Human Anti-TNFRSF12A Recombinant Antibody; Fab Fragment (TAB-219CQ-F(E)) | ELISA, FC, IHC | Humanized Fab |
| TAB-225CQ-F(E) | Human Anti-TNFRSF12A Recombinant Antibody; Fab Fragment (TAB-225CQ-F(E)) | ELISA, FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-220CQ-S(P) | Mouse Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (TAB-220CQ-S(P)) | ELISA, FC, IHC | Mouse scFv |
| TAB-220CQ-F(E) | Human Anti-TNFRSF12A Recombinant Antibody; Fab Fragment (TAB-220CQ-F(E)) | ELISA, FC, IHC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-194LC | Recombinant Anti-Human TNFRSF12A Antibody (Non-glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
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| MOB-2043CT | Recombinant Mouse anti-Human TNFRSF12A Monoclonal antibody (JUFN-2) | FC, FuncS, IHC-Fr, WB | |
| HPAB-0048-LSX | Human Anti-TNFRSF12A Recombinant Antibody (clone TPP-883) | ELISA, WB, FC | Human IgG |
| HPAB-0049-LSX | Human Anti-TNFRSF12A Recombinant Antibody (clone TPP-2090) | ELISA, WB, FC, FuncS | Human IgG |
| HPAB-0050-LSX | Human Anti-TNFRSF12A Recombinant Antibody (clone TPP-2658) | ELISA, WB, FC | Human IgG |
| HPAB-0051-LSX | Human Anti-TNFRSF12A Recombinant Antibody (clone TPP-2084) | ELISA, WB, FC, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3610 | Rabbit Anti-TNFRSF12A Recombinant Antibody (clone DS3610AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0112LY-S(P) | Human Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (HPAB-0112LY-S(P)) | ELISA | Humanized scfv |
| HPAB-0113LY-S(P) | Mouse Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (HPAB-0113LY-S(P)) | ELISA | Mouse scfv |
| HPAB-0114LY-S(P) | Mouse Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (HPAB-0114LY-S(P)) | ELISA | Mouse scfv |
| HPAB-0115LY-S(P) | Mouse Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (HPAB-0115LY-S(P)) | ELISA | Mouse scfv |
| HPAB-0116LY-S(P) | Human Anti-TNFRSF12A Recombinant Antibody; scFv Fragment (HPAB-0116LY-S(P)) | ELISA | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0112LY-F(E) | Human Anti-TNFRSF12A Recombinant Antibody; Fab Fragment (HPAB-0112LY-F(E)) | ELISA | Humanized Fab |
| HPAB-0113LY-F(E) | Mouse Anti-TNFRSF12A Recombinant Antibody; Fab Fragment (HPAB-0113LY-F(E)) | ELISA | Mouse Fab |
| HPAB-0114LY-F(E) | Mouse Anti-TNFRSF12A Recombinant Antibody; Fab Fragment (HPAB-0114LY-F(E)) | ELISA | Mouse Fab |
| HPAB-0115LY-F(E) | Mouse Anti-TNFRSF12A Recombinant Antibody; Fab Fragment (HPAB-0115LY-F(E)) | ELISA | Mouse Fab |
| HPAB-0559-FY-F(E) | Human Anti-TNFRSF12A Recombinant Antibody; Fab Fragment (HPAB-0559-FY-F(E)) | Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY191 | Human Anti-TNFRSF12A (clone TPP-883) scFv-Fc Chimera | FC, ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC657 | Recombinant Anti-TNFRSF12A Vesicular Antibody, EV Displayed (VS-0425-YC657) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7370 | Anti-TNFRSF12A Immunohistochemistry Kit | IHC | |
| VS-0525-XY7371 | Anti-Mouse TNFRSF12A Immunohistochemistry Kit | IHC |
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