Afuco™ Anti-Human TNFRSF18 ADCC Recombinant Antibody (TRX518), ADCC Enhanced (CAT#: AFC-606CL)
Anti-TNFRSF18 ADCC Enhanced Antibody (TRX518) is an ADCC enhanced antibody produced by our Afuco™ platform. TRX518, a novel, humanized monoclonal antibody that is designed to enhance the immune system's anti-tumor response. TRX518 is the first GITR-targeted therapeutic to enter human studies. TRX518 is currently being investigated for the treatment of cancer in a Phase 1 clinical trial.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human spleen
(Immunohistochemical staining of human spleen shows moderate cytoplasmic positivity in red pulp and cells in white pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/ihc_selected.jpg
(Immunohistochemical staining of human spleen shows moderate cytoplasmic positivity in red pulp and cells in white pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/ihc_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_9_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_3.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_5.jpg
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_5_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_5_6.jpg
Figure 6 Bone marrow
(Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_4_4.jpg
(Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_4_4.jpg
Figure 7 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_8_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_8_8.jpg
Figure 8 RNA cell line category: Group enriched (RPMI-8226, SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186891-TNFRSF18
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186891-TNFRSF18
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Melanoma
Product Property
- Purity
- >95% as determined by analysis by RP-HPLC
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- TNFRSF18; tumor necrosis factor receptor superfamily, member 18; AITR; GITR; CD357; GITR-D; tumor necrosis factor receptor superfamily member 18; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein
- Gene ID
- 8784
- UniProt ID
- Q9Y5U5
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TNFRSF18"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-629CL | Human Anti-TNFRSF18 Recombinant Antibody (TAB-629CL) | Activ | Human IgG |
| TAB-098CQ | Human Anti-TNFRSF18 Recombinant Antibody (TAB-098CQ) | ELISA, FC, WB | Humanized antibody |
| TAB-098CQ-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-098CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-098CQ-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (TAB-098CQ-F(E)) | ELISA, FC, WB | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-097CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (TAB-097CQ) | ELISA, FC, WB | Mouse IgG |
| TAB-104CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (TAB-104CQ) | ELISA, FC | Mouse IgG |
| TAB-097CQ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-097CQ-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-104CQ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-104CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-097CQ-F(E) | Mouse Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (TAB-097CQ-F(E)) | ELISA, FC, WB | Mouse Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-105CQ | Human Anti-TNFRSF18 Recombinant Antibody (TAB-105CQ) | ELISA, FC | Chimeric (mouse/human) IgG |
| TAB-105CQ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-105CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-105CQ-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (TAB-105CQ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-099CQ-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-099CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-100CQ-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-100CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-101CQ-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-101CQ-S(P)) | ELISA, FC | Human scFv |
| TAB-099CQ-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (TAB-099CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-100CQ-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (TAB-100CQ-F(E)) | ELISA, FC | Human Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2134CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone 7R12) | FC, Neut, WB | Mouse IgG1 |
| NEUT-2139CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone CBL066) | Neut, FC, WB | Mouse IgG1 |
| NEUT-2140CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone CBL189) | FC, Neut | Mouse IgG1 |
| NEUT-2141CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone MM0312-4Q25) | Neut, FC | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2135CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone CBL318) | Block, FC, ELISA, WB, CyTOF | Mouse IgG1 |
| NEUT-2136CQ | Rat Anti-Tnfrsf18 Recombinant Antibody (clone DTA-1) | Block, FC, IP | Rat IgG2b |
| NEUT-2137CQ | Rat Anti-Tnfrsf18 Recombinant Antibody (clone mAb0860) | Block, FC | Rat IgG2 |
| NEUT-2138CQ | Mouse Anti-Tnfrsf18 Recombinant Antibody (clone YGITR765) | FC, Block | Mouse IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-LS-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-0052-LS-S(P)) | ELISA | Human scFv |
| HPAB-N0397-YC-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-N0397-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0440-WJ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-0440-WJ-S(P)) | ELISA, FC, IHC | Mouse scFv |
| HPAB-0441-WJ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-0441-WJ-S(P)) | ELISA, FC, IHC | Mouse scFv |
| HPAB-0442-WJ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-0442-WJ-S(P)) | ELISA, FC, IHC | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2682LY-F(E) | Mouse Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-2682LY-F(E)) | ELISA, IHC, ECL, WB, IP, FC, IF, RIA | Mouse Fab |
| HPAB-2683LY-F(E) | Mouse Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-2683LY-F(E)) | ELISA, IHC, ECL, WB, IP, FC, IF, RIA | Mouse Fab |
| HPAB-2684LY-F(E) | Mouse Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-2684LY-F(E)) | ELISA, IHC, ECL, WB, IP, FC, IF, RIA | Mouse Fab |
| HPAB-2685LY-F(E) | Mouse Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-2685LY-F(E)) | ELISA, IHC, ECL, WB, IP, FC, IF, RIA | Mouse Fab |
| HPAB-2686LY-F(E) | Mouse Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-2686LY-F(E)) | ELISA, IHC, ECL, WB, IP, FC, IF, RIA | Mouse Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0198-WJ | Human Anti-TNFRSF18 Recombinant Antibody (clone pab1876) | ELISA | Human IgG1 |
| HPAB-1083WJ | Mouse Anti-TNFRSF18 Recombinant Antibody (HPAB-1083WJ) | ELISA, FC, WB | Mouse IgG |
| HPAB-1084WJ | Mouse Anti-TNFRSF18 Recombinant Antibody (HPAB-1084WJ) | ELISA, FC, WB | Mouse IgG |
| HPAB-1085WJ | Mouse Anti-TNFRSF18 Recombinant Antibody (HPAB-1085WJ) | ELISA, FC, WB | Mouse IgG |
| HPAB-1086WJ | Mouse Anti-TNFRSF18 Recombinant Antibody (HPAB-1086WJ) | ELISA, FC, WB | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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