Afuco™ Anti-Human TNFRSF18 ADCC Recombinant Antibody (TRX518), ADCC Enhanced
CAT#: AFC-606CL
Anti-TNFRSF18 ADCC Enhanced Antibody (TRX518) is an ADCC enhanced antibody produced by our Afuco™ platform. TRX518, a novel, humanized monoclonal antibody that is designed to enhance the immune system's anti-tumor response. TRX518 is the first GITR-targeted therapeutic to enter human studies. TRX518 is currently being investigated for the treatment of cancer in a Phase 1 clinical trial.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human spleen
Immunohistochemical staining of human spleen shows moderate cytoplasmic positivity in red pulp and cells in white pulp.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_5_6.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_4_4.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (RPMI-8226, SCLC-21H)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186891-TNFRSF18
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Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Melanoma
Product Property
- Purity
- >95% as determined by analysis by RP-HPLC
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- TNFRSF18; tumor necrosis factor receptor superfamily, member 18; AITR; GITR; CD357; GITR-D; tumor necrosis factor receptor superfamily member 18; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein
- Gene ID
- 8784
- UniProt ID
- Q9Y5U5
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3604z | Mouse Anti-TNFRSF18 Recombinant Antibody (clone 41H7) | WB, ELISA, IHC | Mouse IgG2b |
| HPAB-0052-LS | Human Anti-TNFRSF18 Recombinant Antibody (HPAB-0052-LS) | ELISA, FC, FuncS | Humanized IgG1, κ |
| HPAB-0053-LS | Human Anti-TNFRSF18 Recombinant Antibody (HPAB-0053-LS) | ELISA, FC, FuncS | Humanized IgG1, κ |
| HPAB-N0397-YC | Human Anti-TNFRSF18 Recombinant Antibody (HPAB-N0397-YC) | ELISA, FC | Human IgG4 |
| HPAB-0257-FY | Human Anti-TNFRSF18 Recombinant Antibody (HPAB-0257-FY) | FC, Inhib | Chimeric (mouse/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-629CL | Human Anti-TNFRSF18 Recombinant Antibody (TAB-629CL) | Activ | Human IgG |
| TAB-098CQ | Human Anti-TNFRSF18 Recombinant Antibody (TAB-098CQ) | ELISA, FC, WB | Humanized antibody |
| TAB-098CQ-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-098CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-098CQ-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (TAB-098CQ-F(E)) | ELISA, FC, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0368CL | Human Anti-TNFRSF18 Recombinant Antibody (TAB-0368CL) | ELISA, WB, FuncS, FC, IP | Human IgG |
| TAB-0369CL | Human Anti-TNFRSF18 Recombinant Antibody (TAB-0369CL) | ELISA, WB, FuncS, FC, IP | Human IgG |
| TAB-0370CL | Human Anti-TNFRSF18 Recombinant Antibody (TAB-0370CL) | ELISA, WB, FuncS, FC, IP | Human IgG |
| TAB-0371CL | Human Anti-TNFRSF18 Recombinant Antibody (TAB-0371CL) | ELISA, WB, FuncS, FC, IP | Human IgG |
| TAB-0372CL | Human Anti-TNFRSF18 Recombinant Antibody (TAB-0372CL) | ELISA, WB, FuncS, FC, IP | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-097CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (TAB-097CQ) | ELISA, FC, WB | Mouse IgG |
| TAB-104CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (TAB-104CQ) | ELISA, FC | Mouse IgG |
| TAB-097CQ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-097CQ-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-104CQ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-104CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-097CQ-F(E) | Mouse Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (TAB-097CQ-F(E)) | ELISA, FC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-105CQ | Human Anti-TNFRSF18 Recombinant Antibody (TAB-105CQ) | ELISA, FC | Chimeric (mouse/human) IgG |
| TAB-105CQ-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (TAB-105CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-105CQ-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (TAB-105CQ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2134CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (NEUT-2134CQ) | FC, Neut, WB | Mouse IgG1 |
| NEUT-2139CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone CBL066) | Neut, FC, WB | Mouse IgG1 |
| NEUT-2140CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone CBL189) | FC, Neut | Mouse IgG1 |
| NEUT-2141CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone MM0312-4Q25) | Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2135CQ | Mouse Anti-TNFRSF18 Recombinant Antibody (clone CBL318) | Block, FC, ELISA, WB, CyTOF | Mouse IgG1 |
| NEUT-2136CQ | Rat Anti-Tnfrsf18 Recombinant Antibody (clone DTA-1) | Block, FC, IP | Rat IgG2b |
| NEUT-2137CQ | Rat Anti-Tnfrsf18 Recombinant Antibody (NEUT-2137CQ) | Block, FC | Rat IgG2 |
| NEUT-2138CQ | Mouse Anti-Tnfrsf18 Recombinant Antibody (clone YGITR765) | FC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-LS-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-0052-LS-F(E)) | ELISA | Humanized Fab |
| HPAB-0053-LS-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-0053-LS-F(E)) | ELISA | Humanized Fab |
| HPAB-N0397-YC-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-N0397-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-0257-FY-F(E) | Human Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-0257-FY-F(E)) | FC, Inhib | Chimeric (mouse/human) Fab |
| HPAB-2682LY-F(E) | Mouse Anti-TNFRSF18 Recombinant Antibody; Fab Fragment (HPAB-2682LY-F(E)) | ELISA, IHC, ECL, WB, IP, FC, IF, RIA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-LS-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-0052-LS-S(P)) | ELISA | Human scFv |
| HPAB-0053-LS-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-0053-LS-S(P)) | ELISA | Human scFv |
| HPAB-N0397-YC-S(P) | Human Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-N0397-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-0257-FY-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-0257-FY-S(P)) | FC, Inhib | Mouse scFv |
| HPAB-2682LY-S(P) | Mouse Anti-TNFRSF18 Recombinant Antibody; scFv Fragment (HPAB-2682LY-S(P)) | ELISA, IHC, ECL, WB, IP, FC, IF, RIA | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY45 | Human Anti-TNFRSF18 Agonistic Antibody (VS-0724-XY45) | ELISA, Agonistic assays | Human IgG1 |
| VS-0724-XY46 | Rabbit Anti-Tnfrsf18 Agonistic Antibody (VS-0724-XY46) | FC, WB, IP, Agonistic assays | Rabbit IgG, lambda |
| VS-0724-XY47 | Rat Anti-Tnfrsf18 Agonistic Antibody (clone DTA-1) | FC, WB, IP, Agonistic assays | Rat IgG2a, lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY257 | AbPlus™ Anti-TNFRSF18 Magnetic Beads (VS-0424-XY257) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY220 | CytoStream™ Mouse Anti-TNFRSF18 Recombinant Antibody (VS-0225-XY220) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC273 | Recombinant Anti-TNFRSF18 Vesicular Antibody, EV Displayed (VS-0425-YC273) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7377 | Anti-TNFRSF18 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7378 | Anti-Mouse TNFRSF18 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC338 | SmartAb™ Recombinant Anti-TNFRSF18 pH-dependent Antibody (Clone T10P2H9*B9) | WB, ELISA, IHC | Human IgG1 |
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