What diseases can be studied using the Anti-TNFRSF8 antibody?

This antibody is particularly valuable for studying diseases where CD30 expression is a key factor, including Hodgkin's lymphoma and anaplastic large cell lymphoma. By targeting CD30, researchers can explore its implications in disease pathology and potential therapeutic interventions.

How should the Anti-TNFRSF8 antibody be stored for optimal performance?

It is recommended to store the antibody at -20°C to preserve its functionality and stability over time. Care should be taken to avoid repeated freeze/thaw cycles.

Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (TAB-153)

CAT#: TAB-153

This product is a human IgG1, κ antibody that can recognize human TNFRSF8.

Tested Data Gene Expression

ELISA

Figure 1 Anti-Human CD30 Therapeutic Antibody (TAB-153) in ELISA

ELISA analysis of TAB-153 was performed by coating with Recombinant Human CD30 Protein. Then blocked with BSA, and incubated with Anti-Human CD30 Antibody (TAB-153). The HRP-conjugated goat anti-human IgG as a secondary antibody. Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.

ELISA

Figure 2 Chimeric (mouse/Human) Anti-TNFRSF8 Recombinant Antibody (TAB-153) in ELISA

ELISA analysis of TAB-153 was performed by coating with CD30, Human, Recombinant.
The secondary antibody: HRP-Anti-Human IgG (H+L)

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Subcellular Location Figure 1 IF staining of human cell line HDLM-2

Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg

Subcellular Location Figure 2 IHC staining of human testis

Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg

Subcellular Location Figure 3 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg

Subcellular Location Figure 4 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg

Subcellular Location Figure 5 IF staining of human cell line EFO-21

Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg

Subcellular Location Figure 6 IF staining of human cell line K-562

Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg

Normal Tissue Figure 7 Colon

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg

Normal Tissue Figure 8 Appendix

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 9 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8

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Specifications

Immunogen
Hodgkin's lymphoma cell line L428.

Host Species
Human

Derivation
Chimeric (Mouse/Human)

Type
Human IgG1, κ

Specificity
Human TNFRSF8

Species Reactivity
Human

Applications
Neut, ELISA, IF, IP, FuncS, FC, ICC

Product Property

Purification
Protein A/G Purified

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
This antibody has been reported for use in Neutralization, Enzyme-linked Immunosorbent Assay, Immunofluorescence, Immunoprecipitation, Functional Assay, Flow Cytometry, Immunocytochemistry.

Target

Alternative Names
CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; cytokine receptor CD30; lymphocyte activation antigen CD30

Gene ID
943

UniProt ID
P28908

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Breast cancer biomarkers at key points during disease progression

Great for Flow Cytometry Applications

We have successfully integrated the Anti-TNFRSF8 antibody into our flow cytometry protocols, where its high specificity and sensitivity have provided us with reliable data on CD30 expression, enhancing our understanding of various cellular processes involved in lymphoma progression.

Effective in Lymphoma Research

The Anti-TNFRSF8 Recombinant Antibody has been a fundamental asset in our lymphoma research. Its precision in detecting CD30 expression has allowed us to gain significant insights into the malignancy's behavior and the tumor microenvironment, paving the way for potential therapeutic applications.

Q&As

What diseases can be studied using the Anti-TNFRSF8 antibody?

A: This antibody is particularly valuable for studying diseases where CD30 expression is a key factor, including Hodgkin's lymphoma and anaplastic large cell lymphoma. By targeting CD30, researchers can explore its implications in disease pathology and potential therapeutic interventions.
How should the Anti-TNFRSF8 antibody be stored for optimal performance?

A: It is recommended to store the antibody at -20°C to preserve its functionality and stability over time. Care should be taken to avoid repeated freeze/thaw cycles.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-153, RRID: AB_3111839)

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Biosimilar Overview

Please refer to Brentuximab Vedotin Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Brentuximab Vedotin.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-153.pdf

MSDS

MSDS - TAB-153.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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