Anti-Tim-1 (CR014)-vc-MMAE ADC (CDX-014)
CAT#: ADC-L014
This ADC product is composed of an anti-Tim-1 antibody (clone CR014) conjuagated via a vc linker to MMAE (CR014-vc-MMAE). It has demonstrated a response in ovarian cancer and RCC treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specifications
- Antibody Overview
- Fully human IgG monoclonal antibody that binds to Tim-1
- Clone
- CR014
- Antibody Conjugation
- Human
- Linker
- vc (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- T-cell immunoglobulin and mucin domain 1 (Tim-1) is a receptor for Zaire Ebolavirus and Lake Victoria
Marburgvirus
- Alternative Names
- t cell immunoglobulin domain and mucin domain 1; Tim-1
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See other products for "Tim-1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-975 | Recombinant Anti-Tim-1 Antibody | WB, Dot, FuncS | IgG |
| MHH-975 | Recombinant Human Anti-Tim-1 Antibody | ELISA, WB, FuncS | IgG |
| FAMAB-1499CQ | Mouse Anti-TIM-1 Recombinant Antibody (clone 3B3) | Stim, WB, FC, IF, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-975-F(E) | Recombinant Anti-Tim-1 Antibody Fab Fragment | IF, Neut, FuncS | Fab |
| MHH-975-F(E) | Recombinant Human Anti-Tim-1 Antibody Fab Fragment | ELISA, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-975-S(P) | Recombinant Anti-Tim-1 Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
| MHH-975-S(P) | Recombinant Human Anti-Tim-1 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
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