Anti-Tissue factor (TF-011)-vc-MMAE ADC (HuMax-TF ADC)
CAT#: ADC-L015
This ADC product is composed of an anti-Tissue factor antibody (clone TF-011) conjuagated via a vc linker to MMAE (TF-011-vc-MMAE). It has demonstrated a response in Prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Normal Tissue
Figure 1 Liver
Hepatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_4.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091513-TF
❮
❯
Specifications
- Antibody Overview
- Fully human IgG1K monoclonal antibody that binds to TF
- Clone
- TF-011
- Antibody Conjugation
- Human
- Linker
- vc (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading to fibrin formation.
- Alternative Names
- TF; Tissue factor
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Datasheet
MSDS
COA
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|---|---|---|---|
| PFBL-343 | Mouse Anti-TF Recombinant Antibody (clone 6A6); Fab Fragment | WB, ELISA, IF, FuncS | Mouse Fab |
| PFBW-164 | Mouse Anti-TF Recombinant Antibody (clone JAA-F11); Fab Fragment | FuncS | Mouse Fab |
| FAMAB-0318CQ-F(E) | Mouse Anti-TF Recombinant Antibody (clone PTF.02); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-2578LY-F(E) | Human Anti-TF Recombinant Antibody; Fab Fragment (HPAB-2578LY-F(E)) | ELISA | Humanized Fab |
| HPAB-1276WJ-F(E) | Mouse Anti-TF Recombinant Antibody; Fab Fragment (HPAB-1276WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-121 | Mouse Anti-TF Recombinant Antibody (clone 5G9); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| PSBC-122 | Human Anti-TF Recombinant Antibody (clone hATR-5); scFv Fragment | Block | Humanized scFv |
| HPAB-0717YY-S(P) | Human Anti-TF Recombinant Antibody; scFv Fragment (HPAB-0717YY-S(P)) | ELISA, Inhib, WB, FuncS | Human scFv |
| HPAB-0718YY-S(P) | Human Anti-TF Recombinant Antibody; scFv Fragment (HPAB-0718YY-S(P)) | ELISA, Inhib, WB, FuncS | Human scFv |
| HPAB-0719YY-S(P) | Human Anti-TF Recombinant Antibody; scFv Fragment (HPAB-0719YY-S(P)) | ELISA, Inhib, WB, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0510CL-S(P) | Mouse Anti-TF Recombinant Antibody; scFv Fragment (TAB-0510CL-S(P)) | WB, IF, ELISA | Mouse scFv |
| TAB-0510CL-F(E) | Mouse Anti-TF Recombinant Antibody; Fab Fragment (TAB-0510CL-F(E)) | WB, IF, ELISA | Mouse Fab |
| TAB-598CT | Mouse Anti-TF Recombinant Antibody (TAB-598CT) | ELISA, FC | Mouse IgG1. κ |
| TAB-598CT-S(P) | Mouse Anti-TF Recombinant Antibody; scFv Fragment (TAB-598CT-S(P)) | ELISA, FC | Mouse scFv |
| TAB-598CT-F(E) | Mouse Anti-TF Recombinant Antibody; Fab Fragment (TAB-598CT-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-599CT | Anti-Human TF Recombinant Antibody (ATR-5) | ELISA, FC | Humanized antibody |
| TAB-600CT | Anti-Human TF Recombinant Antibody (ATR-2) | ELISA, FC | Humanized antibody |
| TAB-599CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (ATR-5) | ELISA, FC | Humanized antibody |
| TAB-600CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (ATR-2) | ELISA, FC | Humanized antibody |
| TAB-601CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (ATR-8) | ELISA, FC, BL | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-602CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (3e10) | ELISA, BL | Human antibody |
| TAB-603CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (3h2) | ELISA, BL | Human antibody |
| TAB-604CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (2c1) | ELISA, BL | Human antibody |
| TAB-605CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (2c11) | ELISA, BL | Human antibody |
| TAB-606CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (2d3) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-175LC | Recombinant Anti-Human TF Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0860MZ | Chicken Anti-Transferrin Polyclonal IgY | ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1996CQ | Mouse Anti-TF Recombinant Antibody (clone HTF-14) | WB, Neut, ELISA, ICC, IF, IHC, IHC-P, RIA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2022CQ | Mouse Anti-TF Recombinant Antibody (clone A68-B/A11) | ELISA, Inhib, IHC-P, IHC-Fr | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3535 | Rabbit Anti-TF Recombinant Antibody (clone DS3535AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0767-CN | Human Anti-TF Recombinant Antibody (HPAB-0767-CN) | WB, ELISA, FC, IHC | Human IgG4 |
| HPAB-0768-CN | Human Anti-TF Recombinant Antibody (HPAB-0768-CN) | WB, ELISA, FC, IHC | Human IgG4 |
| HPAB-0769-CN | Human Anti-TF Recombinant Antibody (HPAB-0769-CN) | WB, ELISA, FC, IHC | Human IgG4 |
| HPAB-M0207-YC | Mouse Anti-TF Recombinant Antibody (HPAB-M0207-YC) | ELISA, Inhib | Mouse IgG |
| HPAB-M0208-YC | Human Anti-TF Recombinant Antibody (HPAB-M0208-YC) | ELISA, Inhib | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2269 | Anti-TF Immunohistochemistry Kit | IHC | |
| VS-0525-XY7178 | Anti-Human TF Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC302 | Recombinant Anti-TF Eliminating Antibody, pH-Sensitive (VS-0625-YC302) | Antigen-Sweeping In Vivo. | Rat IgG1 kappa |
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