Anti-Tissue factor (TF-011)-vc-MMAE ADC (HuMax-TF ADC) (CAT#: ADC-L015)

• Antibody Overview
• Fully human IgG1K monoclonal antibody that binds to TF

• Clone
• TF-011

• Antibody Conjugation
• Human

• Linker
• vc (valine-citrulline)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading to fibrin formation.

• Alternative Names
• TF; Tissue factor

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