Anti-Tissue factor (TF-011)-vc-MMAE ADC (HuMax-TF ADC) (CAT#: ADC-L015)
This ADC product is composed of an anti-Tissue factor antibody (clone TF-011) conjuagated via a vc linker to MMAE (TF-011-vc-MMAE). It has demonstrated a response in Prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Normal Tissue
RNA Expression

Figure 1 Liver
(Hepatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_4.jpg
(Hepatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_4.jpg

Figure 2 Kidney
(Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_5.jpg
(Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_5.jpg

Figure 3 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000091513-TF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000091513-TF

Figure 3 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091513-TF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091513-TF
Specifications
- Antibody Overview
- Fully human IgG1K monoclonal antibody that binds to TF
- Clone
- TF-011
- Antibody Conjugation
- Human
- Linker
- vc (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading to fibrin formation.
- Alternative Names
- TF; Tissue factor
Related Resources
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1321z | Mouse Anti-TF Recombinant Antibody (clone 7C1) | ELISA, IHC, FuncS | Mouse IgG1 |
FAMAB-0318CQ | Mouse Anti-TF Recombinant Antibody (clone PTF.02) | ELISA, FC | Mouse IgG1, κ |
FAMAB-0319CQ | Mouse Anti-TF Recombinant Antibody (clone TW4.20) | ELISA | Mouse IgG1, κ |
VS3-QX1090 | Mouse Anti-TF Recombinant Antibody (clone 1A8-7C8-1F3) | IHC, ELISA | Mouse IgG1 |
VS3-QX1091 | Mouse Anti-TF Recombinant Antibody (clone 2B2-3B3-1B7) | IHC, ELISA | Mouse IgG1 |
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