Anti-Tissue factor (TF-011)-vc-MMAE ADC (HuMax-TF ADC)
CAT#: ADC-L015
This ADC product is composed of an anti-Tissue factor antibody (clone TF-011) conjuagated via a vc linker to MMAE (TF-011-vc-MMAE). It has demonstrated a response in Prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091513-TF
Normal Tissue
Figure 1 Liver
Hepatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_4.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
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Specifications
- Antibody Overview
- Fully human IgG1K monoclonal antibody that binds to TF
- Clone
- TF-011
- Antibody Conjugation
- Human
- Linker
- vc (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading to fibrin formation.
- Alternative Names
- TF; Tissue factor
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Specific Tissue Factor Binding
The clone TF-011 in this ADC exhibits high specificity for Tissue Factor, the key initiator of the coagulation cascade. In our prostate cancer cell models, this product demonstrated clear binding and internalization, facilitating the study of targeted drug delivery via this well-characterized surface antigen.
Enzymatic Linker Reliability
The valine-citrulline (vc) peptide linker in this conjugate offers the stability we need for systemic circulation simulations while ensuring rapid enzymatic release in the target cell lysosomes. The resulting depolymerization of microtubules by MMAE was evident in our cellular assays, confirming the product's effectiveness.
Q&As
-
How is the drug released from the vc linker?
A: The vc (valine-citrulline) linker is an enzymatically cleavable peptide linker. Its scission relies on lysosomal proteolytic enzymes, which are abundant inside the target cell but have very low activity in the blood, combining systemic stability with rapid intracellular release.
-
What is the role of the target, Tissue Factor?
A: Tissue factor (TF) is the key initiator of the coagulation cascade. It acts as a receptor that binds factor VIIa, resulting in the activation of factor IX and factor X, which ultimately leads to fibrin formation. It is also expressed on certain tumor cells.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
MSDS
COA
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Lot Number:
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|---|---|---|---|
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| PABL-343 | Mouse Anti-TF Recombinant Antibody (clone 6A6) | WB, ELISA, IF, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
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| PSBL-343 | Mouse Anti-TF Recombinant Antibody (clone 6A6); scFv Fragment | WB, ELISA, IF, FuncS | Mouse scFv |
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| CAT | Product Name | Application | Type |
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| PFBW-121 | Mouse Anti-TF Recombinant Antibody (clone 5G9); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-122 | Human Anti-TF Recombinant Antibody (clone hATR-5); Fab Fragment | Block | Humanized Fab |
| CAT | Product Name | Application | Type |
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| PFBW-164 | Mouse Anti-TF Recombinant Antibody (clone JAA-F11); Fab Fragment | FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-121 | Mouse Anti-TF Recombinant Antibody (clone 5G9); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-122 | Human Anti-TF Recombinant Antibody (clone hATR-5); scFv Fragment | Block | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-164 | Mouse Anti-TF Recombinant Antibody (clone JAA-F11); scFv Fragment | FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0510CL | Mouse Anti-TF Recombinant Antibody (TAB-0510CL) | WB, IF, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0510CL-S(P) | Mouse Anti-TF Recombinant Antibody; scFv Fragment (TAB-0510CL-S(P)) | WB, IF, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
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| TAB-0510CL-F(E) | Mouse Anti-TF Recombinant Antibody; Fab Fragment (TAB-0510CL-F(E)) | WB, IF, ELISA | Mouse Fab |
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|---|---|---|---|
| TAB-599CT | Anti-Human TF Recombinant Antibody (ATR-5) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
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| TAB-600CT | Anti-Human TF Recombinant Antibody (ATR-2) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-601CT | Anti-Human TF Recombinant Antibody (ATR-8) | ELISA, FC, BL | Humanized antibody |
| CAT | Product Name | Application | Type |
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| TAB-602CT | Anti-Human TF Recombinant Antibody (3e10) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-603CT | Anti-Human TF Recombinant Antibody (3h2) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-604CT | Anti-Human TF Recombinant Antibody (2c1) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CT | Anti-Human TF Recombinant Antibody (2c11) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-606CT | Anti-Human TF Recombinant Antibody (2d3) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-598CT-S(P) | Mouse Anti-TF Recombinant Antibody; scFv Fragment (TAB-598CT-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-599CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (ATR-5) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-600CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (ATR-2) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-175LC | Recombinant Anti-Human TF Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0860MZ | Chicken Anti-Transferrin Polyclonal IgY | ELISA | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1106 | PE-H2-Aa/Gallus gallus TF (GNSHRGAIEWEGIESG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1107 | APC-H2-Aa/Gallus gallus TF (GNSHRGAIEWEGIESG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1108 | BV421-H2-Aa/Gallus gallus TF (GNSHRGAIEWEGIESG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1996CQ | Mouse Anti-TF Recombinant Antibody (clone HTF-14) | WB, Neut, ELISA, ICC, IF, IHC, IHC-P, RIA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2022CQ | Mouse Anti-TF Recombinant Antibody (clone A68-B/A11) | ELISA, Inhib, IHC-P, IHC-Fr | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3535 | Rabbit Anti-TF Recombinant Antibody (clone DS3535AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0318CQ-F(E) | Mouse Anti-TF Recombinant Antibody (clone PTF.02); Fab Fragment | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0318CQ-S(P) | Mouse Anti-TF Recombinant Antibody (clone PTF.02); scFv Fragment | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2269 | Anti-TF Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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| VS-0525-XY7178 | Anti-Human TF Immunohistochemistry Kit | IHC |
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