Recombinant Mouse Anti-TrkA Antibody (MNAC13)

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Citations

1. Guo, Zhiliang, Yuanyuan Liu, and Min Cheng. "Resveratrol protects bupivacaine-induced neuro-apoptosis in dorsal root ganglion neurons via activation on tropomyosin receptor kinase A." Biomedicine & Pharmacotherapy 103 (2018): 1545-1551. https://doi.org/10.1016/j.biopha.2018.04.155
   This research investigated whether resveratrol (RSV) could protect against bupivacaine (BUP)-induced neurotoxicity in spinal cord dorsal root ganglia (DRG). Using cultured mouse DRG neurons, the study demonstrated that RSV exhibited significant protective effects against BUP-induced neuro-apoptosis in a concentration-dependent manner. The researchers found that while RSV did not alter TrkA/B/C gene or protein expression, it significantly upregulated phosphorylated TrkA. When a functional TrkA blocking antibody (MNAC13) was applied, the protective effects of RSV were reversed, demonstrating that RSV's neuroprotective activity against anesthesia-induced apoptosis operates primarily through activation of the TrkA signaling pathway.
   Creative Biolabs provided the functional TrkA blocking antibody MNAC13 used in this study, which was crucial for confirming the mechanism of RSV-mediated neuroprotection. By applying MNAC13 to inhibit TrkA signaling, the researchers were able to demonstrate that phospho-TrkA upregulation was essential for RSV's protective effect, as blocking this pathway reversed the anti-apoptotic benefits. This antibody tool enabled the researchers to conclusively identify TrkA activation as the underlying mechanism through which RSV protects against anesthesia-induced neurotoxicity, providing valuable insights for potential therapeutic interventions to prevent neural damage during spinal anesthesia.

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Publications

Peer-reviewed Publications

Our products have been used extensively by scientists all over the world to accelerate their life science research. Here, we present a collection of publications that cite this product.

Guo, Zhiliang, Yuanyuan Liu, and Min Cheng. "Resveratrol protects bupivacaine-induced neuro-apoptosis in dorsal root ganglion neurons via activation on tropomyosin receptor kinase A." Biomedicine & Pharmacotherapy 103 (2018): 1545-1551.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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