Anti-Human UPAR Recombinant Antibody (19.1) (CAT#: TAB-0395CL)
This monoclonal antibody, specific for urokinase-type plasminogen activator receptor (uPAR), can be used for the treatment or prevention of cancer.
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Inhib
Figure 1 Inhibition of uPAR-dependent adhesion of HEK293 cells on vitronectin by mAbs from epitope bin 6.
The inhibitory effects of anti-uPAR mAbs (100 nM) belonging to epitope bin 6 (mAbs 8B12 and 19.10) and bin 1 (mAb R21) were compared on adherent HEK293 cells. The HEK293 cells were induced to adhere firmly on vitronectin by their surface expression of uPARwt, uPARwt·ATF complexes (formed by addition of 50 nM ATF), or uPARH47C-N259C. Cellular protrusions were scored 24 h after addition of the respective mAbs or buffer controls and each bar represents the mean value of three independent measurements (a protrusion index of 100% signifies that all 18 micrographs examined were scored positive for the presence of lamellipodia by both evaluators). Note the that the y-axis has been shifted upwards to allow the visualization of zero values.
Mandik-Nayak, L., DuHadaway, J. B., Mulgrew, J., Pigott, E., Manley, K., Sedano, S., ... & Laury-Kleintop, L. D. (2017). RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus. Disease models & mechanisms, 10(11), 1313-1322.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 19.1
- Applications
- Inhib
- Related Disease
- Pprevent, ameliorate, or treat a disease (such as prostate cancer) or disorder
Applications
- Application Notes
- The uPAR antibody has been reported in applications of Inhibition.
Target
- Alternative Names
- Urokinase receptor; uPA receptor; uPAR; CD87; Cluster of Differentiation 87; Urokinase Plasminogen Activator Receptor
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
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Mouse Antibody Products
Human Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1024 | Recombinant Anti-uPAR Antibody | WB, IP, FuncS | IgG |
| MHH-1024 | Recombinant Human Anti-uPAR Antibody | ELISA, IP, FuncS | IgG |
| PABC-130 | Mouse Anti-UPAR Recombinant Antibody (clone ATN615) | ELISA, IP, WB, IHC, IF, FuncS | Mouse IgG |
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