Human Anti-VEGFA Recombinant Antibody (clone 5A12) (CAT#: PABL-358)
Recombinant Human Antibody (5A12) is capable of binding to VEGF, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-VEGF mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-VEGF mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Figure 1 Affinity improved variants with sub-nanomolar dual affinity show similar blocking activity as mono-specific antibodies.
In vitro receptor blocking assay to compare the blocking of hAng2 binding to Tie2 by 5A12, the high affinity 5A12 variants, and the mono-specific hAng2 and hVEGF antibody G5.5 and G6.31, respectively.
Koenig, P., Lee, C. V., Sanowar, S., Wu, P., Stinson, J., Harris, S. F., & Fuh, G. (2015). Deep sequencing-guided design of a high affinity dual specificity antibody to target two angiogenic factors in neovascular age-related macular degeneration. Journal of Biological Chemistry, 290(36), 21773-21786.
Specifications
- Immunogen
- Human vascular endothelial growth factor A
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human VEGFA
- Species Reactivity
- Human
- Clone
- 5A12
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Blocking.
Target
- Alternative Names
- VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
- Gene ID
- 7422
- UniProt ID
- P15692
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-011 | Anti-Human VEGF Recombinant Antibody (Bevacizumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-012-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (TAB-012-F(E)) | IP, IF, FuncS, FC, Neut, ELISA, IHC | Fab - G1 - kappa |
| TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
| TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
| TAB-307CQ-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-307CQ-F(E)) | ELISA, Neut | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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