anti-VEGFA immunotoxin Ng76 (scFv)-Luffin-β
CAT#: AGTO-L043L
This immunotoxin was achieved by conjugating/fusing the Anti-VEGFA scFv to loofah toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to melanoma cells and the toxin enters cells by receptor-mediated endocytosis. Then loofah toxin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of melanoma.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_B_7_5.jpg
Normal Tissue
Figure 2 Thyroid gland
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_B_1_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_5_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39240/82308_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1, U-87 MG)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112715-VEGFA
❮
❯
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- Ng76
- Molecule Class
- scFv-Luffin-β
- Toxin Description
- Loofah toxin (Luffin-β), is separated from the silk seeds into type I ribosome inactivating protein (ribosomeinactivating protein, RIP), RIP gourd. There are many types, mainly Luffin-a, Luffin-β, Luffin-Ss, Luffin-cylin, Luffin-Pl, which Luffin-β point containing 278 amino acids, the molecular weight of 30. 583KD, etc. 9.5, capable of specifically hydrolyzing eukaryotic ribosomes 28SrRNA4324 bit of adenine, so true 60s nuclear large subunit of ribosomes inactivate significantly inhibit protein synthesis, is one of the most active single-chain RIP are currently in, is of concern immunotoxin new powerful warhead small molecule recent years
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Melanoma
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for AGTO-L043L. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone Ng76"
- CAT
- Product Name
See other products for "VEGFA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H73 | Anti-Human VEGFA Recombinant Antibody (TAB-H73) | WB, FC, IP, ELISA, Neut, FuncS, IF | VH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappa |
| TAB-011 | Anti-Human VEGF Recombinant Antibody (Bevacizumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
| TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
| TAB-009ML | Anti-Human VEGFA Recombinant Antibody scFv Fragment (TAB-009ML) | ELISA, IHC, FC, IP, IF, Inhib | scFv, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-284CQ | Human Anti-VEGFA Recombinant Antibody (TAB-284CQ) | WB | Human antibody |
| TAB-304CQ | Anti-Human VEGFA Recombinant Antibody (2H1) | ELISA | Human antibody |
| TAB-284CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-284CQ-S(P)) | ELISA | Human scFv |
| TAB-304CQ-S(P) | Anti-Human VEGFA Recombinant Antibody scFv Fragment (2H1) | ELISA, WB | Human antibody |
| TAB-305CQ-S(P) | Anti-Human VEGFA Recombinant Antibody scFv Fragment (2H1-32) | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-306CQ | Mouse Anti-VEGFA Recombinant Antibody (TAB-306CQ) | FuncS, Inhib | Mouse IgG |
| TAB-306CQ-S(P) | Mouse Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-306CQ-S(P)) | ELISA, Neut | Mouse scFv |
| TAB-306CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-306CQ-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0623MZ | Chicken Anti-VEGF Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2255CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL198) | Neut, WB | Mouse IgG1 |
| NEUT-2256CQ | Rat Anti-Vegfa Recombinant Antibody (clone 2G11-2A05) | WB, Neut, ELISA, IHC, FuncS | Rat IgG2a, κ |
| NEUT-2257CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 16F1) | WB, Neut | Mouse IgG2a |
| NEUT-2258CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 4B2-8) | ELISA, Neut, WB | Mouse IgG1, κ |
| NEUT-2260CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL737) | WB, ELISA, Neut | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2259CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A.4.6.1) | ELISA, IP, WB, Block, FC, IHC | Mouse IgG1, κ |
| NEUT-2267CQ | Mouse Anti-VEGFA Recombinant Antibody (NEUT-2267CQ) | WB, Block | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3835 | Rabbit Anti-VEGFA Recombinant Antibody (clone DS3835AB) | FC, ICC, IF, IHC-P, IP, WB | Rabbit IgG |
| MOR-4758 | Rabbit Anti-Vegfa Recombinant Antibody (clone TH272DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0151-FY | Human Anti-VEGFA Recombinant Antibody (clone rhVVH) | WB, ELISA, Inhib | Human IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0151-FY-F(E) | Human Anti-VEGFA Recombinant Antibody (clone rhVVH); Fab Fragment | WB, ELISA, Inhib | Human Fab |
| HPAB-M0242-YC-F(E) | Human Anti-VEGFA Recombinant Antibody (clone B5E3); Fab Fragment | ELISA | Humanized Fab |
| HPAB-M0243-YC-F(E) | Human Anti-VEGFA Recombinant Antibody (clone Bev-B5E3BsAb); Fab Fragment | ELISA, Block, Inhib | Humanized Fab |
| HPAB-N0295-YC-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-N0295-YC-F(E)) | ELISA | Human Fab |
| HPAB-N0296-YC-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-N0296-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-465CQ | Afuco™ Anti-VEGFA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-465CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-011 | Afuco™ Anti-VEGFA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-011) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0348-WJ-S(P) | Human Anti-VEGFA Recombinant Antibody (clone 7F2); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0349-WJ-S(P) | Human Anti-VEGFA Recombinant Antibody (clone 6B2); scFv Fragment | ELISA | Humanized scFv |
| HPAB-M0372-YC-S(P) | Canine Anti-VEGFA Recombinant Antibody; scFv Fragment (HPAB-M0372-YC-S(P)) | ELISA, Inhib, FuncS | Mouse scFv |
| HPAB-M0373-YC-S(P) | Canine Anti-VEGFA Recombinant Antibody; scFv Fragment (HPAB-M0373-YC-S(P)) | ELISA, Inhib, FuncS | Mouse scFv |
| HPAB-M0374-YC-S(P) | Canine Anti-VEGFA Recombinant Antibody; scFv Fragment (HPAB-M0374-YC-S(P)) | ELISA, Inhib, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0242-YC | Human Anti-VEGFA Recombinant Antibody (clone B5E3) | ELISA | Humanized IgG |
| HPAB-M0243-YC | Human Anti-VEGFA Recombinant Antibody (clone Bev-B5E3BsAb) | ELISA, Block, Inhib | Humanized IgG |
| HPAB-0006-YJ | Human Anti-VEGFA Recombinant Antibody (clone Y0317) | ELISA, FuncS, In vivo | Humanized IgG1, κ |
| HPAB-0060-YJ | Mouse Anti-VEGFA Recombinant Antibody (clone 2C3) | FuncS, IHC, WB, Block, ELISA, IP | Mouse IgG2a, κ |
| HPAB-0418-YJ | Human Anti-VEGFA Recombinant Antibody (clone CBV59YJ) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0310-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (HPAB-N0310-YC-VHNAR) | ELISA, FC, WB | Shark vNAR |
| HPAB-N0311-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (HPAB-N0311-YC-VHNAR) | ELISA, FC, WB | Shark vNAR |
| HPAB-0337-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (HPAB-0337-YJ-vNAR) | FC, ELISA, Inhib, Neut | Shark vNAR |
| HPAB-0338-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (HPAB-0338-YJ-vNAR) | FC, ELISA, Inhib, Neut | Shark vNAR |
| NBD-0090-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (NBD-0090-YJ-VHH) | ELISA, WB, Inhib | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY273 | AbPlus™ Anti-VEGFA Magnetic Beads (A.4.6.1) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY540 | Mouse Anti-NHP VEGFA Recombinant Antibody (clone 26503) | WB, ELISA | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY46 | Human Anti-VEGFA (clone G6-31) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC709 | Recombinant Anti-VEGFA Vesicular Antibody, EV Displayed (VS-0425-YC709) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC190 | Recombinant Anti-VEGFA (N-terminus x C-terminus) Biparatopic Antibody, Tandem scFv (Clone C1039 x Clone c870) | ELISA | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: ELISA
Application: FuncS, Inhib, IP, ELISA
Application: WB, ELISA, Neut, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: ELISA, Activ, Block
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
