Anti-N. meningitidis fHbp Recombinant Antibody (502) (CAT#: TAB-070WM)

Figure 1 Inhibition of binding of a fixed concentration (1 mg/ml) of anti-fHbp mAbs to recombinant fHbp as measured by ELISA.

Red triangles: inhibition of binding of mAb502 (IgG2a) by JAR 1 (IgG3). Green circles: Inhibition of binding of JAR 1 by mAb502.

Giuntini, S., Beernink, P. T., Reason, D. C., & Granoff, D. M. (2012). Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. PloS one, 7(3).

Figure 2 Inhibition of fH binding to live bacteria of wild-type group B strain H44/76 as measured by flow cytometry.

The source of human fH was 20% IgG-depleted human serum.

Giuntini, S., Beernink, P. T., Reason, D. C., & Granoff, D. M. (2012). Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. PloS one, 7(3).

Figure 3 Binding of chimeric mAbs to fHbp by ELISA using anti-human kappa light chain secondary antibody.

Red triangles with solid red line, chimeric JAR 1; Green circles with dashed line, chimeric mAb502

Giuntini, S., Beernink, P. T., Reason, D. C., & Granoff, D. M. (2012). Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. PloS one, 7(3).