Anti-N. meningitidis fHbp Recombinant Antibody (502) (CAT#: TAB-070WM)
A mouse monoclonal anti-N. meningitidis fHbp antibody, this antibody is bactericidal and recognizes a conformational epitope within a well-defined area of the immunodominant C-terminal domain of fHbp. It may be potentially used for the treatment and prevention of disease caused by Neisseria meningitidis, such as meningococcal meningitis, septicaemia or hemorrhagic disease, particularly in humans.
Specific Inquiry
Inhib
Figure 1 Inhibition of binding of a fixed concentration (1 mg/ml) of anti-fHbp mAbs to recombinant fHbp as measured by ELISA.
Red triangles: inhibition of binding of mAb502 (IgG2a) by JAR 1 (IgG3). Green circles: Inhibition of binding of JAR 1 by mAb502.
Giuntini, S., Beernink, P. T., Reason, D. C., & Granoff, D. M. (2012). Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. PloS one, 7(3).
FC
Figure 2 Inhibition of fH binding to live bacteria of wild-type group B strain H44/76 as measured by flow cytometry.
The source of human fH was 20% IgG-depleted human serum.
Giuntini, S., Beernink, P. T., Reason, D. C., & Granoff, D. M. (2012). Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. PloS one, 7(3).
ELISA
Figure 3 Binding of chimeric mAbs to fHbp by ELISA using anti-human kappa light chain secondary antibody.
Red triangles with solid red line, chimeric JAR 1; Green circles with dashed line, chimeric mAb502
Giuntini, S., Beernink, P. T., Reason, D. C., & Granoff, D. M. (2012). Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. PloS one, 7(3).
Specifications
- Host Species
- Mouse
- Specificity
- N. meningitidis
- Species Reactivity
- N. meningitidis
- Clone
- 502
- Applications
- ELISA, FC, Inhib
- Related Disease
- Meningococcal meningitis
Applications
- Application Notes
- The N. meningitidis fHbp antibody has been reported in applications of Inhibition, Flow Cytometry, Enzyme-linked Immunosorbent Assay. FC: A fixed concentration of fH (,90 mg/ml) was incubated with 2 mg/ml of JAR 1, or 2 or 50 mg/ml of mAb502.
Target
- Alternative Names
- fHbp; Fa; Factor H binding protein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-070WM-S(P) | Anti-N. meningitidis fHbp Recombinant Antibody scFv Fragment (502) | WB, FC | |
| TAB-070WM-F(E) | Anti-N. meningitidis fHbp Recombinant Antibody Fab Fragment (502) | WB, FC |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-841CQ | Recombinant Mouse Anti-fhbP Antibody (JAR5) | ELISA, WB, BL | IgG2b, κ |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0136CQ | Recombinant Human Anti-fHbp Antibody (chJAR 1) | ELISA, FC, Inhib | Chimeric (mouse/human) IgG1 |
| FAMAB-0137CQ | Recombinant Human Anti-fHbp Antibody (chJAR 3) | ELISA, WB, BL, FC | Chimeric (mouse/human) IgG1 |
| FAMAB-0138CQ | Recombinant Human Anti-fHbp Antibody (chJAR 5) | ELISA, WB, BL, FC | Chimeric (mouse/human) IgG1 |
| FAMAB-0139CQ | Recombinant Mouse Anti-fHbp Antibody (JAR 1) | ELISA, FC, WB, Inhib | Mouse IgG3 |
| FAMAB-0140CQ | Recombinant Mouse Anti-fHbp Antibody (JAR 3) | ELISA, WB, Block, FC | Mouse IgG3 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0136CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 1) | ELISA, FC, Inhib | Chimeric (mouse/human) Fab |
| FAMAB-0137CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 3) | ELISA, WB, BL, FC | Chimeric (mouse/human) Fab |
| FAMAB-0138CQ-F(E) | Recombinant Human Anti-fHbp Antibody Fab Fragment (chJAR 5) | ELISA, WB, BL, FC | Chimeric (mouse/human) Fab |
| FAMAB-0139CQ-F(E) | Recombinant Mouse Anti-fHbp Antibody Fab Fragment (JAR 1) | ELISA, FC, Inhib | Mouse Fab |
| FAMAB-0140CQ-F(E) | Recombinant Mouse Anti-fHbp Antibody Fab Fragment (JAR 3) | ELISA, WB, BL, FC | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0139CQ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 1) | ELISA, FC, Inhib | Mouse scFv |
| FAMAB-0140CQ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 3) | ELISA, WB, BL, FC | Mouse scFv |
| HPAB-0023-WJ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR41) | ELISA, FC, DB, Inhib | Mouse scFv |
| HPAB-0766-WJ-S(P) | Recombinant Mouse Anti-fHbp Antibody scFv Fragment (JAR 64) | ELISA, WB | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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