BV421-A*02:01/CMV pp65 (NLVPMVATV) MHC Tetramer
CAT#: MHC-LC224
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of CMV-derived peptide of NLVPMVATV sequence covering 495-503 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- CMV pp65
- Antigen Species
- CMV
- Peptide
- NLVPMVATV
- Range
- 495-503
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is typically abbreviated as HCMV or, commonly but more ambiguously, as CMV. It is also known as human herpesvirus-5 (HHV-5). pp65 (ppUL83), the major constituent of both virions and noninfectious particles called dense bodies, localizes predominantly to the nucleus after virus penetration and accumulates in both nucleus and cytoplasm as virus matures late in infection, where it may associate with a kinase.
- Alternative Names
- CMV pp65; Human cytomegalovirus pp65; UL83; lower matrix protein
- Gene ID
- 911829
- UniProt ID
- Q05320
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Outstanding CMV pp65 Detection
The BV421-labeled A*02:01 tetramer for CMV pp65 (495-503) provided exceptional results. We could clearly identify the NLVPMVATV-specific CD8 T cells in human PBMC samples. The signal was distinct and integrated well into our multicolor flow cytometry panels.
Reliable Tool For Viral Studies
We consistently use this tetramer to monitor immune responses to Human cytomegalovirus. The reagent is stable and specific, allowing us to accurately enumerate antigen-specific T cells. It is a vital tool for our research on viral latency and reactivation.
Q&As
-
What is the role of the pp65 protein in CMV infection?
A: The pp65 (ppUL83) protein is the major constituent of the tegument of human cytomegalovirus virions. It is a lower matrix protein that localizes to the nucleus after infection and is a primary target of the CD8 T cell response to CMV.
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Which human MHC allele is used in this tetramer?
A: This tetramer uses the HLA-A*02:01 allele, which is a common human MHC Class I molecule. It presents the NLVPMVATV peptide from CMV pp65 to CD8 T cells.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| PFBC-118 | Recombinant Human Anti-CMV pp65 Antibody Fab Fragment (MO61) | BL |
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| MRO-1562CQ | Recombinant Mouse Anti-CMV pp65 Antibody (CMV100) | IF | Mouse antibody |
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| MRO-1563CQ | Recombinant Mouse Anti-CMV pp65 Antibody (CMV101) | IF | Mouse antibody |
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| MRO-1564CQ | Recombinant Mouse Anti-CMV pp65 Antibody (0885) | IF | Mouse antibody |
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| MHC-LC230 | BV421-A*24:02/CMV pp65 (QYDPVAALF) MHC Tetramer | FCM |
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| MHC-LC234 | BV421-B*07:02/CMV pp65 (TPRVTGGGAM) MHC Tetramer | FCM |
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| MHC-LC236 | PE-B*35:01/CMV pp65 (IPSINVHHY) MHC Tetramer | FCM |
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| MHC-LC237 | APC-B*35:01/CMV pp65 (IPSINVHHY) MHC Tetramer | FCM |
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