BV421-DRB1*04:01/Human COL2A1 (AYMRADAAAGGA) MHC Tetramer (CAT#: MHC-LC1072)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of COL2A1-derived peptide of AYMRADAAAGGA covering 1169-1173 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55753/1472_C7_4_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55753/1472_C7_4_selected.jpg
Figure 2 IHC staining of human cartilage
(Immunohistochemical staining of human cartilage shows moderate cytoplasmic positivity in the chondrocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/2214/1552_866_400x400.jpg
(Immunohistochemical staining of human cartilage shows moderate cytoplasmic positivity in the chondrocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/2214/1552_866_400x400.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2214/169753_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2214/169753_B_7_5.jpg
Figure 4 RNA cell line category: Cell line enhanced (AF22, HAP1, HEK93)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139219-COL2A1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139219-COL2A1
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- COL2A1
- Antigen Species
- Human
- Peptide
- AYMRADAAAGGA
- Range
- 1169-1173
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
- Alternative Names
- COL2A1; collagen type II alpha 1 chain; AOM; ANFH; SEDC; STL1; COL11A3
- Gene ID
- 1280
- UniProt ID
- P02458
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-225-F(E) | Recombinant Anti-human COL2A1 Antibody Fab Fragment | FC, WB, FuncS | Fab |
| MHH-225-F(E) | Recombinant Human Anti-human COL2A1 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| PFBZ-088 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC4); Fab Fragment | ELISA, IP, IHC | Mouse Fab |
| HPAB-0281-YC-F(E) | Human Anti-COL2A1 Recombinant Antibody; Fab Fragment (HPAB-0281-YC-F(E)) | ELISA, IHC, FuncS | Human Fab |
| PFBC-248 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC1); Fab Fragment | ELISA, IHC | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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