BV421-DRB1*04:01/Human COL2A1 (AYMRADAAAGGA) MHC Tetramer (CAT#: MHC-LC1072)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of COL2A1-derived peptide of AYMRADAAAGGA covering 1169-1173 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55753/1472_C7_4_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55753/1472_C7_4_selected.jpg
Figure 2 IHC staining of human cartilage
(Immunohistochemical staining of human cartilage shows moderate cytoplasmic positivity in the chondrocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/2214/1552_866_400x400.jpg
(Immunohistochemical staining of human cartilage shows moderate cytoplasmic positivity in the chondrocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/2214/1552_866_400x400.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2214/169753_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2214/169753_B_7_5.jpg
Figure 4 RNA cell line category: Cell line enhanced (AF22, HAP1, HEK93)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139219-COL2A1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139219-COL2A1
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- COL2A1
- Antigen Species
- Human
- Peptide
- AYMRADAAAGGA
- Range
- 1169-1173
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
- Alternative Names
- COL2A1; collagen type II alpha 1 chain; AOM; ANFH; SEDC; STL1; COL11A3
- Gene ID
- 1280
- UniProt ID
- P02458
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-225-F(E) | Recombinant Anti-human COL2A1 Antibody Fab Fragment | FC, WB, FuncS | Fab |
| MHH-225-F(E) | Recombinant Human Anti-human COL2A1 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| PFBZ-088 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC4); Fab Fragment | ELISA, IP, IHC | Mouse Fab |
| PFBL-644 | Mouse Anti-COL2A1 Recombinant Antibody (clone M2139); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0281-YC-F(E) | Human Anti-COL2A1 Recombinant Antibody; Fab Fragment (HPAB-0281-YC-F(E)) | ELISA, IHC, FuncS | Human Fab |
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