BV421-DRB1*04:01/Human COL2A1 (AYMRADAAAGGA) MHC Tetramer
CAT#: MHC-LC1072
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of COL2A1-derived peptide of AYMRADAAAGGA covering 1169-1173 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55753/1472_C7_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cartilage
Immunohistochemical staining of human cartilage shows moderate cytoplasmic positivity in the chondrocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/2214/1552_866_400x400.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2214/169753_B_7_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, HAP1, HEK93)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139219-COL2A1
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Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- COL2A1
- Antigen Species
- Human
- Peptide
- AYMRADAAAGGA
- Range
- 1169-1173
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
- Alternative Names
- COL2A1; collagen type II alpha 1 chain; AOM; ANFH; SEDC; STL1; COL11A3
- Gene ID
- 1280
- UniProt ID
- P02458
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COA
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