BV421-H-2Db/LCMV gp33 (KAVYNFATC) MHC Tetramer
CAT#: MHC-LC284
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of LCMV-derived peptide of KAVYNFATC sequence covering 33-41 and H-2Db molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2Db
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- LCMV gp33
- Antigen Species
- LCMV
- Peptide
- KAVYNFATC
- Range
- 33-41
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae. The name was coined by Charles Armstrong in 1934.
- Alternative Names
- LCMV GP1; Lymphocytic choriomeningitis virus Glycoprotein 1
- Gene ID
- 1491875
- UniProt ID
- P26804
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Clarity in T Cell Detection
The BV421 fluorophore offers exceptional clarity, which facilitates the accurate identification of LCMV-specific T cells. This has significantly improved the precision of our flow cytometry analyses, making it a vital tool in our virology research.
High Sensitivity and Specificity in Detection
As part of our immunological toolkit, this tetramer's high sensitivity and specificity ensure it captures even subtle immune responses, which are essential for comprehensive viral immunology research.
Q&As
-
What should be considered when storing the MHC tetramer to maintain effectiveness?
A: Proper storage at recommended temperatures, typically around 4°C in the dark, is essential to preserve the fluorescence integrity and binding capacity of the tetramer over time.
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How does the BV421 fluorophore enhance the utility of this MHC tetramer?
A: The BV421 fluorophore provides a bright, consistent, and stable fluorescent signal, which enhances the visibility and distinction of antigen-specific T cells in flow cytometry, facilitating precise cell enumeration and phenotyping.
View the frequently asked questions answered by Creative Biolabs Support.
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