BV421-H-2Db/Mouse (WMHHNMDLI) MHC Tetramer
CAT#: MHC-LC675
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of HY Uty-derived peptide of WMHHNMDLI sequence covering 246-254 and H-2Db molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/568/1659_B_7_5.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/568/1659_A_7_4.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/568/1659_A_4_6.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/568/1659_A_8_8.jpg
Normal Tissue
Figure 5 Tonsil
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/568/1659_A_5_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HEL, SK-MEL-30, U-266/84, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183878-UTY
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Specifications
- Allele
- H-2Db
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- HY Uty
- Antigen Species
- Mouse
- Peptide
- WMHHNMDLI
- Range
- 246-254
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined.
- Alternative Names
- Uty; Ubiquitously transcribed tetratricopeptide repeat gene
- Gene ID
- 22290
- UniProt ID
- Q3UQE8
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Specific Uty Antigen Staining
The BV421-labeled H-2Db tetramer for the HY Uty peptide WMHHNMDLI was crucial for our minor histocompatibility antigen research. We detected specific CD8 T cells in male-graft recipient mice with high clarity.
Reliable Reagent For HY Study
We used this product to investigate rejection responses to the Uty protein. The tetramer's specificity for the target peptide was excellent, allowing us to accurately enumerate the relevant immune cells in our transplant models.
Q&As
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What is the Uty protein and its relevance?
A: Uty (Ubiquitously transcribed tetratricopeptide repeat gene, Y-linked) is a protein encoded on the Y chromosome. It acts as a minor histocompatibility antigen (HY antigen) and can induce graft rejection of male stem cell grafts in female recipients.
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What is the peptide sequence recognized by this H-2Db tetramer?
A: This tetramer recognizes the peptide sequence WMHHNMDLI (residues 246-254) derived from the mouse Uty protein. It allows for the specific detection of HY-specific CD8 T cells.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "UTY"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4030z | Mouse Anti-UTY Recombinant Antibody (clone 23H4) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2192CT | Recombinant Mouse anti-Human UTY Monoclonal antibody (20D0) | ELISA, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC674 | APC-H-2Db/Mouse (WMHHNMDLI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC688 | PE-H-2Db/Mouse (WMHHNMDLI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF209 | H-2Db/Mouse HY Uty (WMHHNMDLI) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-CJ58 | Mouse Anti-UTY Recombinant Antibody (VS3-CJ58) | WB, ELISA | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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