Benralizumab
CAT#: Gly-006CL
Benralizumab (INN) is a monoclonal antibody which is being developed by MedImmune for the treatment of asthma. It is directed against the alpha-chain of the interleukin-5 receptor (CD125).
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091181-IL5RA
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Specifications
- Type
- Humanized (from mouse) Whole antibody
- Protein chemical formula
- C6492H10060N1724O2028S42
- Protein average weight
- 146.0 kg/mol
- CAS number
- 1044511-01-4
- Class
- Antiasthmatics; Monoclonal antibodies
- Mechanism of action
- Interleukin 5 receptor antagonists
References
- Synonyms
- MEDI-563 (BIW-8405); Anti-IL-5Rα Mab; Anti-IL5Ra monoclonal antibody; Anti-interleukin-5 receptor alpha monoclonal antibody; BIW-8405-IL-5R; KHK 4563;
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Excellent Eosinophil Depletion
We used this antibody in our asthma research models to deplete eosinophils. The afucosylated Fc region clearly enhances its ADCC activity, as we observed near-complete depletion of the target cells in our ex vivo blood assays.
High Quality Reagent
The antibody quality is top-notch. It binds specifically to the IL-5 receptor alpha chain as described, and we have used it successfully for both flow cytometry staining and functional depletion studies with consistent results across different experiments.
Q&As
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What is the target of Benralizumab and its effect on eosinophils?
A: Benralizumab specifically targets the alpha chain of the interleukin-5 receptor (IL-5Rα), which is expressed on eosinophils. The binding of this antibody blocks IL-5 signaling and, due to its afucosylated Fc region, recruits NK cells to actively deplete eosinophils via ADCC.
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Why is the afucosylation of this antibody important for research?
A: Afucosylation (removal of fucose) from the Fc region dramatically increases the antibody's affinity for FcγRIIIa on immune effector cells. In a research setting, this allows for the study of potent, direct cell-killing mechanisms, distinguishing it from antibodies that merely block receptor signaling without inducing depletion.
View the frequently asked questions answered by Creative Biolabs Support.
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