Products

Anti-BAFF × Anti-B7RP1 Bispecific Antibody (TAND-L006)

Recombinant Anti-BAFF × Anti-B7RP1 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb can inhibit B cell survival and T cell costimulation. It was designed for the treatment of systemic lupus erythematosus.      

Specifications
Targets
BAFF & B7RP1
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
BAFF
Host
Mouse
Target 2
B7RP1
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
systemic lupus erythematosus
Targets
Target 1
BAFF
Gene ID
10673
UniProt ID
Q9Y275
Alternative Names
DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1
Target 2
B7RP1
Gene ID
23308
UniProt ID
O75144
Alternative Names
B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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