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Anti-CD19 × Anti-CD47 Bispecific Antibody (TAND-L040)

Recombinant Anti-CD19 × Anti-CD47 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. It was designed for the treatment of Burkitt lymphoma.      

Specifications
Targets
CD19 & CD47
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
CD19
Host
Mouse
Clone
RFB9
Target 2
CD47
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Burkitt lymphoma
Targets
Target 1
CD19
Gene ID
930
UniProt ID
P15391
Alternative Names
CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4
Target 2
CD47
Gene ID
961
UniProt ID
Q08722
Alternative Names
CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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