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Anti-CD28 × Anti-melanoma-associated proteoglycan Bispecific Antibody (TAND-L056)

Recombinant Anti-CD28 × Anti-melanoma-associated proteoglycan Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. The BsAb can induce a TCR/CD3 independent, "supraagonistic" stimulation of the CD28 molecule on resting human T cells, which depends on tumor cell binding and results in tumor cell killing. It was designed for the treatment of melanoma.      

Specifications
Targets
CD28 & melanoma-associated proteoglycan
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
CD28
Host
Mouse
Clone
15E8
Target 2
melanoma-associated proteoglycan
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Melanoma
Targets
Target 1
CD28
Gene ID
940
UniProt ID
B4E0L1
Alternative Names
CD28; CD28 molecule; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen
Target 2
melanoma-associated proteoglycan
Gene ID
1464
UniProt ID
Q6UVK1
Alternative Names
NG2; chondroitin sulfate proteoglycan 4; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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