Products

Anti-EGFR × Anti-ErbB-3 Bispecific Antibody (DVD-Ig, DVD1) (DVD-MZ017)

This anti-EGFR/ErbB3 DVD-Ig protein shows the best proliferation inhibition in A431 and FaDu cells, both of which express relatively high levels of EGFR and ErbB3. It is also capable of inhibiting cancer cell proliferation by blocking cell signaling including PI3K/AKT and Ras/MAPK pathways.      

  • Datasheet

Specifications
Targets
EGFR & ErbB-3
Type
DVD-Ig
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Human
Target 2
ErbB-3
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
ELISA
Related Disease
Epidermoid carcinoma, Hypopharyngeal carcinoma
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
ErbB-3
Gene ID
2065
UniProt ID
P21860
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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