Products

Anti-EGFR × Anti-FcγRIII Bispecific Antibody (CROSS-L001)

Recombinant Anti-EGFR × Anti-FcγRIII Bispecific Antibody (CrossMab) has been generated by applying the Crossmab format to generate an IgG shaped entity that binds each ligand with one arm. This BsAb is capable of targeting the tumor and recruiting NK effector cells via binding to the FcγRIII of the NK cells. It was designed for the treatment of renal cell carcinoma.      

  • Datasheet

Specifications
Targets
EGFR & FcγRIII
Type
CrossMab
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Human
Clone
H425
Target 2
FcγRIII
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Renal cell carcinoma
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
FcγRIII
Gene ID
2214
UniProt ID
M9MML0
Alternative Names
FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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