Products

Anti-EGFR × Anti-IGFR Bispecific Antibody (DVD-L002)

Recombinant Anti-EGFR × Anti-IGFR Bispecific Antibody (DVD-Ig) is comprised of a whole EGFR-binding 'IgG' (with Fc region) and additional variable regions that bind IGF1R fused 'on top' of the existing variable regions. This BsAb is capable of blocking EGFR as well as IGFR simultaneously. BsAb-mediated simultaneous interference with two (or more) RTK signaling pathways, by inactivating either the RTKs or their ligand, can reduce the possibility of such escape mechanisms and, hence, improve therapeutic efficacy by inhibiting their signaling and suppressing tumor cells growth. It was designed for the treatment of badder cancer; brain cancer; head and neck cancer; pancreatic cancer; lung cancer; breast cancer; ovarian cancer; colon cancer; prostate cancer; kidney cancer.      

  • Datasheet

Specifications
Targets
EGFR & IGFR
Type
DVD-Ig
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Human
Clone
ICR62
Target 2
IGFR
Host
Human
Clone
HUMAB Clone 18
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Bladder cancer; Brain cancer; Head and neck cancer; Pancreatic cancer; Lung cancer; Breast cancer; Ovarian cancer; Colon cancer; Prostate cancer; Kidney cancer
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
IGFR
Gene ID
3480
UniProt ID
P08069
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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