Products

Anti-FXIa × Anti-FX Bispecific Antibody (TAND-L010)

Recombinant Anti-FXIa × Anti-FX Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains, are smaller than whole IgGs or IgG-derived BsAbs, but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. The cognate antigens that are bound by this bispecific antibody are Factor IXa and Factor X in the coagulation cascade. In healthy subjects, these factors are brought together by coagulation factor VIIIa, which is missing in the bleeding disorder hemophilia A. It was designed for the treatment of bleeding disorder hemophilia A.      

Specifications
Targets
FXIa & FX
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
FXIa
Host
Mouse
Target 2
FX
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Bleeding disorder hemophilia A
Targets
Target 1
FXIa
Gene ID
2158
UniProt ID
P00740
Alternative Names
F9; coagulation factor IX; FIX; P19; PTC; HEMB; THPH8; F9 p22
Target 2
FX
Gene ID
2159
UniProt ID
P00742
Alternative Names
F10; coagulation factor X; FX; FXA; factor Xa; prothrombinase; Stuart-Prower factor

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-381-2994    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2018 Creative-Biolabs All Rights Reserved