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Anti-FcαRI × Anti-HLA class II Bispecific Antibody (TAND-L025)

Recombinant Anti-FcαRI × Anti-HLA class II Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb can retarget of neutrophils to tumor cells. It was designed for the treatment of lymphoma.      

Specifications
Targets
FcαRI & HLA class II
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
FcαRI
Host
Human
Target 2
HLA class II
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Lymphoma
Targets
Target 1
FcαRI
Gene ID
2204
UniProt ID
P24071
Alternative Names
CD89; FcalphaRI; CTB-61M7.2
Target 2
HLA class II
Gene ID
3123
UniProt ID
P01912
Alternative Names
HLA-DRB1; major histocompatibility complex, class II, DR beta 1; SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B; DW2.2/DR2.2; HLA class II histocompatibility antigen, DR-1 beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class II antigen; human leucocyte antigen DRB1; lymphocyte antigen DRB1

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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