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Anti-HER1 × Anti-HER3 Bispecific Antibody (TAND-L012)

Recombinant Anti-HER1 × Anti-HER3 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of blocking HER1 as well as HER3 simultaneously. BsAb-mediated simultaneous interference with two (or more) RTK signaling pathways, by inactivating either the RTKs or their ligand, can reduce the possibility of such escape mechanisms and, hence, improve therapeutic efficacy. It was designed for the treatment of head and neck cancer, colorectal cancer.      

Specifications
Targets
HER1 & HER3
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
HER1
Host
Human
Target 2
HER3
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Head and neck cancer; Colorectal cancer
Targets
Target 1
HER1
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
HER3
Gene ID
2065
UniProt ID
P21860
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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