Products

Anti-HER2 × Anti-CD3 Bispecific Antibody (FAB-L053)

Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (F(ab')2) is a chemical conjugate composed of the Fab' of the anti-HER2 monoclonal antibody and Fab' of an antibody specific for CD3. A stable thioether linkage is formed between the two Fab'. The bispecific antibody is somewhat smaller than a whole IgG, and therefore it clears from the blood naturally at a faster rate. This BsAb is capable of targeting the tumor and recruiting T effector cells via binding to the CD3 subunit of the T cell receptor complex. It was designed for the treatment of ovarian and breast carcinomas.      

Specifications
Targets
HER2 & CD3
Type
F(ab')2
Species Reactivity
Human
Target 1
HER2
Host
Mouse
Target 2
CD3
Host
Mouse
Clone
OKT3
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Ovarian and breast carcinomas
Targets
Target 1
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Target 2
CD3
Gene ID
916
UniProt ID
P07766
Alternative Names
CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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