Recombinant Anti-HER2 × Anti-HER2 Bispecific Antibody (CrossMab)
CAT#: CROSS-L012
Recombinant Anti-HER2 × Anti-HER2(dual epitope targeting) Bispecific Antibody (CrossMab) has been generated by applying the Crossmab format to generate an IgG shaped entity that binds each ligand with one arm. This BsAb is capable of blocking two HER family members has been demonstrated by simultaneously blocking HER2 well as HER2 (dual epitope targeting). BsAb-mediated simultaneous interference with two (or more) RTK signaling pathways, by inactivating either the RTKs or their ligand, should reduce the possibility of such escape mechanisms and, hence, improve therapeutic efficacy. It was designed for the treatment of breast cancer ;prostate cancer; non-small cell lung cancer; bladder cancer; ovarian cancer; gastric cancer; colon cancer; esophageal cancer.
Specifications
- Target
- HER2 & HER2
- Type
- CrossMab
- Species Reactivity
- Human
- Target 1
- HER2
- Host Species 1
- Macacamulatta
- Target 2
- HER2
- Host Species 2
- Macacamulatta
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Breast cancer; Prostate cancer; Non-small cell lung cancer; Bladder cancer; Ovarian cancer; Gastric cancer; Colon cancer; Esophageal cancer
Target
- Target 1
- HER2
- Gene ID
- 2064
- UniProt ID
- P04626
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1
- Target 2
- HER2
- Gene ID
- 2064
- UniProt ID
- P04626
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
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