Products

Anti-IL17A × Anti-TNF Bispecific Antibody (TAND-L016)

Recombinant Anti-IL17A × Anti-TNF Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of blocking two proinflammatory cytokines and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of rheumatoid arthritis.      

Specifications
Targets
IL17A & TNF
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
IL17A
Host
Mouse
Target 2
TNF
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Rheumatoid arthritis
Targets
Target 1
IL17A
Gene ID
3605
UniProt ID
Q16552
Alternative Names
IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8
Target 2
TNF
Gene ID
7124
UniProt ID
P01375
Alternative Names
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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